Nature Communications (Jul 2019)

IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation

  • Kyuho Kang,
  • Mahesh Bachu,
  • Sung Ho Park,
  • Keunsoo Kang,
  • Seyeon Bae,
  • Kyung-Hyun Park-Min,
  • Lionel B. Ivashkiv

DOI
https://doi.org/10.1038/s41467-019-11147-3
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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Macrophage activation is synergistically controlled by lipopolysaccharide (LPS) and interferon-γ (IFN-γ). Here the authors show that IFN-γ promotes macrophage activation not only by activating STAT1-dependent genes, but also by suppressing STAT3-dependent negative feedback regulation downstream of LPS signaling.