Cancers (Mar 2023)

A Feasibility Study of Functional Lung Volume Preservation during Stereotactic Body Radiotherapy Guided by Gallium-<sup>68</sup> Perfusion PET/CT

  • François Lucia,
  • Mohamed Hamya,
  • Fanny Pinot,
  • Gaëlle Goasduff,
  • Frédérique Blanc-Béguin,
  • David Bourhis,
  • Olivier Pradier,
  • Anne-Sophie Lucia,
  • Simon Hennebicq,
  • Maëlle Mauguen,
  • Romain Floch,
  • Ulrike Schick,
  • Vincent Bourbonne,
  • Pierre-Yves Salaün,
  • Pierre-Yves Le Roux

DOI
https://doi.org/10.3390/cancers15061726
Journal volume & issue
Vol. 15, no. 6
p. 1726

Abstract

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The aim of this study was to assess the feasibility of sparing functional lung areas by integration of pulmonary functional mapping guided by 68Ga-perfusion PET/CT imaging in lung SBRT planification. Sixty patients that planned to receive SBRT for primary or secondary lung tumors were prospectively enrolled. Lung functional volumes were defined as the minimal volume containing 50% (FV50%), 70% (FV70%) and 90% (FV90%) of the total activity within the anatomical volume. All patients had a treatment planning carried out in 2 stages: an anatomical planning blinded to the PET results and then a functional planning respecting the standard constraints but also incorporating “lung functional volume” constraints. The mean lung dose (MLD) in functional volumes and the percentage of lung volumes receiving xGy (VxGy) within the lung functional volumes using both plans were calculated and compared. SBRT planning optimized to spare lung functional regions led to a significant reduction (p 68Ga-perfusion PET/CT while still respecting target volume coverage and doses to other organs at risk.

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