Ketebalan Tunika Intima dan Media Arteri Karotis Komunis pada Karsinoma Nasofaring Pra dan Pascaradioterapi

Abstract

External radiotherapy is the main treatment for nasopharyngeal carcinoma. External radiotherapy can cause endothelial dysfunction of common carotid artery and reduces nitrogen oxide and prostacyclin by endothelial cell and cause thickening of the vessels walls. Purpose of this study was to find out changes in intima-media thickness and lumen diameter of common carotid artery due to radiotherapy in patients with nasopharyngeal carcinoma. This research was descriptive with pre and post design and performed from March 2009 to February 2010 in the Ear Nose Throat-Head Neck Surgery Department of Dr. Hasan Sadikin Hospital Bandung. Gray scale ultrasound examination was performed before, after and ten weeks after radiotherapy and calculated by using Fischer’s test and paired T test. They were 25 subjects and was found out 0.1 mm additional thickness in right intima media and 0.09 mm in left intima media common carotid artery (p<0.001), also found reduction in lumen diameter of common carotid artery in which 0.384 mm in the right and 0.342 mm in the left (p<0.001). In conclusions, external radiotherapy can cause increase intima media thickness and reduction lumen diameter in common carotid artery in patients with nasopharyngeal carcinoma.

Keywords

• External beam irradiation
• intima media thickness
• lumen diameter
• nasopharyngeal carcinoma