Molecules
(Sep 2019)
Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents
Anastasia L. Khandazhinskaya,
Elena S. Matyugina,
Pavel N. Solyev,
Maggie Wilkinson,
Karen W. Buckheit,
Robert W. Buckheit,
Larisa N. Chernousova,
Tatiana G. Smirnova,
Sofya N. Andreevskaya,
Khalid J. Alzahrani,
Manal J. Natto,
Sergey N. Kochetkov,
Harry P. de Koning,
Katherine L. Seley-Radtke
Affiliations
Anastasia L. Khandazhinskaya
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia
Elena S. Matyugina
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia
Pavel N. Solyev
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia
Maggie Wilkinson
ImQuest BioSciences, 7340 Executive Way Suite R, Frederick, MD 21704, USA
Karen W. Buckheit
ImQuest BioSciences, 7340 Executive Way Suite R, Frederick, MD 21704, USA
Robert W. Buckheit
ImQuest BioSciences, 7340 Executive Way Suite R, Frederick, MD 21704, USA
Larisa N. Chernousova
Central Tuberculosis Research Institute, 2 Yauzskaya Alley, Moscow 107564, Russia
Tatiana G. Smirnova
Central Tuberculosis Research Institute, 2 Yauzskaya Alley, Moscow 107564, Russia
Sofya N. Andreevskaya
Central Tuberculosis Research Institute, 2 Yauzskaya Alley, Moscow 107564, Russia
Khalid J. Alzahrani
Institute of Infection, Immunity and Inflammation, University of Glasgow, Sir Graeme Davies Building, 120 University Place, Glasgow G12 8TA, UK
Manal J. Natto
Institute of Infection, Immunity and Inflammation, University of Glasgow, Sir Graeme Davies Building, 120 University Place, Glasgow G12 8TA, UK
Sergey N. Kochetkov
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia
Harry P. de Koning
Institute of Infection, Immunity and Inflammation, University of Glasgow, Sir Graeme Davies Building, 120 University Place, Glasgow G12 8TA, UK
Katherine L. Seley-Radtke
Department of Chemistry & Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
DOI
https://doi.org/10.3390/molecules24193433
Journal volume & issue
Vol. 24,
no. 19
Abstract
Read online
Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both Mycobacterium tuberculosis and several parasitic strains. As a result, a small structure activity relationship study was designed to further probe their activity and potential. Their synthesis and the results of the subsequent biological activity are reported herein.
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