Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents

Anastasia  L. Khandazhinskaya; Elena  S. Matyugina; Pavel  N. Solyev; Maggie Wilkinson; Karen  W. Buckheit; Robert  W. Buckheit; Larisa  N. Chernousova; Tatiana  G. Smirnova; Sofya  N. Andreevskaya; Khalid  J. Alzahrani; Manal  J. Natto; Sergey  N. Kochetkov; Harry  P. de Koning; Katherine  L. Seley-Radtke

doi:10.3390/molecules24193433

Molecules (Sep 2019)

Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents

Anastasia L. Khandazhinskaya,
Elena S. Matyugina,
Pavel N. Solyev,
Maggie Wilkinson,
Karen W. Buckheit,
Robert W. Buckheit,
Larisa N. Chernousova,
Tatiana G. Smirnova,
Sofya N. Andreevskaya,
Khalid J. Alzahrani,
Manal J. Natto,
Sergey N. Kochetkov,
Harry P. de Koning,
Katherine L. Seley-Radtke

Affiliations

Anastasia L. Khandazhinskaya: Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia
Elena S. Matyugina: Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia
Pavel N. Solyev: Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia
Maggie Wilkinson: ImQuest BioSciences, 7340 Executive Way Suite R, Frederick, MD 21704, USA
Karen W. Buckheit: ImQuest BioSciences, 7340 Executive Way Suite R, Frederick, MD 21704, USA
Robert W. Buckheit: ImQuest BioSciences, 7340 Executive Way Suite R, Frederick, MD 21704, USA
Larisa N. Chernousova: Central Tuberculosis Research Institute, 2 Yauzskaya Alley, Moscow 107564, Russia
Tatiana G. Smirnova: Central Tuberculosis Research Institute, 2 Yauzskaya Alley, Moscow 107564, Russia
Sofya N. Andreevskaya: Central Tuberculosis Research Institute, 2 Yauzskaya Alley, Moscow 107564, Russia
Khalid J. Alzahrani: Institute of Infection, Immunity and Inflammation, University of Glasgow, Sir Graeme Davies Building, 120 University Place, Glasgow G12 8TA, UK
Manal J. Natto: Institute of Infection, Immunity and Inflammation, University of Glasgow, Sir Graeme Davies Building, 120 University Place, Glasgow G12 8TA, UK
Sergey N. Kochetkov: Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia
Harry P. de Koning: Institute of Infection, Immunity and Inflammation, University of Glasgow, Sir Graeme Davies Building, 120 University Place, Glasgow G12 8TA, UK
Katherine L. Seley-Radtke: Department of Chemistry & Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA

DOI: https://doi.org/10.3390/molecules24193433
Journal volume & issue: Vol. 24, no. 19
p. 3433

Abstract

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Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both Mycobacterium tuberculosis and several parasitic strains. As a result, a small structure activity relationship study was designed to further probe their activity and potential. Their synthesis and the results of the subsequent biological activity are reported herein.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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