The Efficacy of Preventing Rachitis in Babies by Using Vitamin D Solutio Oleosa: the Results of a Short-Term Comparative Investigation

Abstract

Background: Vitamin D-deficient states remain highly prevalent in children, according to Russian and foreign studies. Because of this, it is important to conduct timely prevention of rachitis in children, taking into account the commitment to therapy from the parents’ side.Objective: Our aim was to study the preventive efficacy of the Russian-manufactured vitamin D3 solutio oleosa with regard to preventing rachitis.Methods: A short-term prospective comparative study has been conducted. Vitamin D3 was used in the dosages of 400 and 800 ME or 500 and 1000 ME, in the form of an oil or water solution of cholecalciferol in mature and premature (according to the gestation term) children, correspondingly. The control group was comprised of mature children of a comparable age, who received no vitaminoprophilaxis (parental refusal). We evaluate clinical symptoms of rachitis before and after 1 month after the beginning of the study.Results: 111 children aged 4–6 months, of them 66 mature and 45 premature were included into the study. None of the children developed rachitis symptoms while taking vitamin D3 while 8 out of 15 controls (53%) developed signs of rachitis.Conclusion: We demonstrated a comparative efficacy of oil and water solutions of vitamin D3 with regard to preventing rachitis in mature and premature children.

Keywords

• children
• vitamin d
• deficit
• rachitis
• prevention
• efficacy