Nature Communications (Feb 2016)
Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts
- Liang Ma,
- Zehua Chen,
- Da Wei Huang,
- Geetha Kutty,
- Mayumi Ishihara,
- Honghui Wang,
- Amr Abouelleil,
- Lisa Bishop,
- Emma Davey,
- Rebecca Deng,
- Xilong Deng,
- Lin Fan,
- Giovanna Fantoni,
- Michael Fitzgerald,
- Emile Gogineni,
- Jonathan M. Goldberg,
- Grace Handley,
- Xiaojun Hu,
- Charles Huber,
- Xiaoli Jiao,
- Kristine Jones,
- Joshua Z. Levin,
- Yueqin Liu,
- Pendexter Macdonald,
- Alexandre Melnikov,
- Castle Raley,
- Monica Sassi,
- Brad T. Sherman,
- Xiaohong Song,
- Sean Sykes,
- Bao Tran,
- Laura Walsh,
- Yun Xia,
- Jun Yang,
- Sarah Young,
- Qiandong Zeng,
- Xin Zheng,
- Robert Stephens,
- Chad Nusbaum,
- Bruce W. Birren,
- Parastoo Azadi,
- Richard A. Lempicki,
- Christina A. Cuomo,
- Joseph A. Kovacs
Affiliations
- Liang Ma
- Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USA
- Zehua Chen
- Genome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of Technology
- Da Wei Huang
- Leidos BioMedical Research, Inc., Frederick National Laboratory for Cancer Research
- Geetha Kutty
- Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USA
- Mayumi Ishihara
- Complex Carbohydrate Research Center, University of Georgia
- Honghui Wang
- Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USA
- Amr Abouelleil
- Genome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of Technology
- Lisa Bishop
- Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USA
- Emma Davey
- Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USA
- Rebecca Deng
- Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USA
- Xilong Deng
- Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USA
- Lin Fan
- Genome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of Technology
- Giovanna Fantoni
- Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USA
- Michael Fitzgerald
- Genome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of Technology
- Emile Gogineni
- Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USA
- Jonathan M. Goldberg
- Genome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of Technology
- Grace Handley
- Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USA
- Xiaojun Hu
- Leidos BioMedical Research, Inc., Frederick National Laboratory for Cancer Research
- Charles Huber
- Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USA
- Xiaoli Jiao
- Leidos BioMedical Research, Inc., Frederick National Laboratory for Cancer Research
- Kristine Jones
- Leidos BioMedical Research, Inc., Frederick National Laboratory for Cancer Research
- Joshua Z. Levin
- Genome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of Technology
- Yueqin Liu
- Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USA
- Pendexter Macdonald
- Genome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of Technology
- Alexandre Melnikov
- Genome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of Technology
- Castle Raley
- Leidos BioMedical Research, Inc., Frederick National Laboratory for Cancer Research
- Monica Sassi
- Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USA
- Brad T. Sherman
- Leidos BioMedical Research, Inc., Frederick National Laboratory for Cancer Research
- Xiaohong Song
- Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USA
- Sean Sykes
- Genome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of Technology
- Bao Tran
- Leidos BioMedical Research, Inc., Frederick National Laboratory for Cancer Research
- Laura Walsh
- Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USA
- Yun Xia
- Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USA
- Jun Yang
- Leidos BioMedical Research, Inc., Frederick National Laboratory for Cancer Research
- Sarah Young
- Genome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of Technology
- Qiandong Zeng
- Genome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of Technology
- Xin Zheng
- Leidos BioMedical Research, Inc., Frederick National Laboratory for Cancer Research
- Robert Stephens
- Leidos BioMedical Research, Inc., Frederick National Laboratory for Cancer Research
- Chad Nusbaum
- Genome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of Technology
- Bruce W. Birren
- Genome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of Technology
- Parastoo Azadi
- Complex Carbohydrate Research Center, University of Georgia
- Richard A. Lempicki
- Leidos BioMedical Research, Inc., Frederick National Laboratory for Cancer Research
- Christina A. Cuomo
- Genome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of Technology
- Joseph A. Kovacs
- Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USA
- DOI
- https://doi.org/10.1038/ncomms10740
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
Pneumocystis jirovecii is a fungus that can cause life-threatening pneumonia in immunocompromised patients. Here, the authors sequence the genomes of P. jirovecii and two other Pneumocystisspecies, and show the unexpected absence of chitin (a near universal fungal cell wall component).
