Zhongguo cuzhong zazhi (Jul 2024)

药物涂层球囊与普通球囊血管成形术治疗症状性颅内动脉粥样硬化性狭窄的安全性和预后对比研究 Comparative Study on the Safety and Prognosis of Drug-Coated Balloon Angioplasty and Conventional Balloon Angioplasty in the Treatment of Symptomatic Intracranial Atherosclerotic Stenosis

  • 李彦江1，刘彤晖1，田惠2，孙岩1，张勇1 (LI Yanjiang1, LIU Tonghui1, TIAN Hui2, SUN Yan1, ZHANG Yong1 )

DOI
https://doi.org/10.3969/j.issn.1673-5765.2024.07.011
Journal volume & issue
Vol. 19, no. 7
pp. 803 – 808

Abstract

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目的 对比分析药物涂层球囊（drug-coated balloon，DCB）和普通球囊血管成形术治疗症状性颅内动脉粥样硬化性重度狭窄患者的安全性和预后。 方法 回顾性分析2020年3月—2022年4月在青岛大学附属医院进行治疗的症状性颅内动脉粥样硬化性重度狭窄患者，按照治疗方式的不同分为DCB组和普通球囊组。比较两组患者的一般临床资料、疗效和安全性终点，包括围手术期并发症、临床结局和影像随访结果。 结果 研究共纳入49例患者，其中DCB组30例，普通球囊组19例。两组的基线资料、围手术期并发症、术后6个月内再发卒中率、再狭窄率及死亡率差异均无统计学意义（P>0.05）；6个月随访DCB组狭窄程度为14.50%（9.55%～23.42%），低于普通球囊组的30.00%（15.42%～37.61%），差异有统计学意义（P＝0.027）。 结论 与普通球囊相比，DCB治疗症状性颅内动脉粥样硬化性重度狭窄是安全的，可以有效降低目标血管再狭窄的进展。 Abstract: Objective To compare the safety and prognosis of drug-coated balloon (DCB) angioplasty and conventional balloon angioplasty in treating symptomatic intracranial atherosclerotic stenosis. Methods The patients with symptomatic severe intracranial atherosclerotic stenosis who were treated at The Affiliated Hospital of Qingdao University from March 2020 to April 2022 were retrospectively analyzed. Patients were divided into the DCB group and the conventional balloon group according to the treatment method. The general clinical data, efficacy, and safety endpoints, including perioperative complications, clinical outcomes, and imaging results during follow-up, were compared between the two groups. Results A total of 49 patients were included in the study, including 30 in the DCB group and 19 in the conventional balloon group. There were no significant differences in baseline data and perioperative complications, as well as stroke recurrence rate, restenosis rate and mortality within 6 months after surgery between the two groups (P>0.05). The DCB group exhibited a lower degree of restenosis at 14.50% (9.55%-23.42%), as compared to 30.00% (15.42%-37.61%) in the conventional balloon group, with a statistically significant difference (P=0.027). Conclusions In comparison to conventional balloon treatment, DCB treatment is considered safe for symptomatic severe intracranial atherosclerotic stenosis and can effectively reduce the progress of target vessel restenosis.

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