Identification of emergent blaCMY-2-carrying Proteus mirabilis lineages by whole-genome sequencing

M. Mac Aogáin; T.R. Rogers; B. Crowley

doi:10.1016/j.nmni.2015.11.012

New Microbes and New Infections (Jan 2016)

Identification of emergent blaCMY-2-carrying Proteus mirabilis lineages by whole-genome sequencing

M. Mac Aogáin,
T.R. Rogers,
B. Crowley

Affiliations

M. Mac Aogáin: Department of Clinical Microbiology, Sir Patrick Dun Translational Research Laboratory, School of Medicine, Trinity College Dublin, Dublin, Ireland
T.R. Rogers: Department of Clinical Microbiology, Sir Patrick Dun Translational Research Laboratory, School of Medicine, Trinity College Dublin, Dublin, Ireland
B. Crowley: Department of Clinical Microbiology, Sir Patrick Dun Translational Research Laboratory, School of Medicine, Trinity College Dublin, Dublin, Ireland

DOI: https://doi.org/10.1016/j.nmni.2015.11.012
Journal volume & issue: Vol. 9, no. C
pp. 58 – 62

Abstract

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Whole-genome sequencing of 24 Proteus mirabilis isolates revealed the clonal expansion of two cefoxitin-resistant strains among patients with community-onset infection. These strains harboured blaCMY-2 within a chromosomally located integrative and conjugative element and exhibited multidrug resistance phenotypes. A predominant strain, identified in 18 patients, also harboured the PGI-1 genomic island and associated resistance genes, accounting for its broader antibiotic resistance profile. The identification of these novel multidrug-resistant strains among community-onset infections suggests that they are endemic to this region and represent emergent P. mirabilis lineages of clinical significance.

Published in New Microbes and New Infections

ISSN: 2052-2975 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: https://www.sciencedirect.com/journal/new-microbes-and-new-infections

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