Chinese Journal of Contemporary Neurology and Neurosurgery (Feb 2021)

Progress on hematoma expansion mechanism and hemostatic therapy of spontaneous intracerebral hemorrhage

  • LI Yu⁃jian,
  • ZHENG Jun

Journal volume & issue
Vol. 21, no. 2
pp. 94 – 100

Abstract

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Spontaneous intracerebral hemorrhage (SICH) is a severe subtype of stroke. Hematoma expansion could occur in the short term after symptom onset in most patients, leading to neurological deterioration and mortality. Therefore, early hemostasis treatment is essential to save patients' lives and improve prognosis. Currently, the hemostatic agents used for intracerebral hemorrhage are mainly antifibrinolytic drugs and recombinant activated factor Ⅶ. However, there is no decisive evidence for the clinical benefit of hemostatic drugs in patients with intracerebral hemorrhage. To provide reference for clinical choice of drugs, this article reviews the hematoma expansion mechanism and hemostatic therapy of spontaneous intracerebral hemorrhage. doi:10.3969/j.issn.1672⁃6731.2021.02.006

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