PLoS ONE (Jan 2022)

A network meta-analysis of 12,116 individuals from randomized controlled trials in the treatment of depression after acute coronary syndrome.

  • Grace En Hui Lim,
  • Ansel Tang,
  • Yip Han Chin,
  • Jie Ning Yong,
  • Darren Tan,
  • Phoebe Tay,
  • Yu Yi Chan,
  • Denzel Ming Wei Lim,
  • Jun Wei Yeo,
  • Kai En Chan,
  • Kamala Devi,
  • Colin Eng Choon Ong,
  • Roger S Y Foo,
  • Huay-Cheem Tan,
  • Mark Y Chan,
  • Roger Ho,
  • Poay Huan Loh,
  • Nicholas W S Chew

DOI
https://doi.org/10.1371/journal.pone.0278326
Journal volume & issue
Vol. 17, no. 11
p. e0278326

Abstract

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BackgroundPost-acute coronary syndrome (ACS) depression is a common but not well understood complication experienced by ACS patients. Research on the effectiveness of various therapies remains limited. Hence, we sought to conduct a network meta-analysis to assess the efficacy of different interventions for post-ACS depression in improving patient outcomes.Methods and findingsThree electronic databases were searched for randomised controlled trials describing different depression treatment modalities in post-ACS patients. Each article was screened based on inclusion criteria and relevant data were extracted. A bivariate analysis and a network meta-analysis was performed using risk ratios (RR) and standardized mean differences (SMD) for binary and continuous outcomes, respectively. A total of 30 articles were included in our analysis. Compared to standard care, psychosocial therapy was associated with the greatest reduction in depression scores (SMD:-1.21, 95% CI: -1.81 to -0.61, pConclusionThis network meta-analysis found that the treatment effect of the various psychological modalities on depression severity were similar. Future trials on psychological interventions assessing clinical outcomes and improvement in adherence to ACS-specific interventions are needed.