Presence of orexin A and orexin 1 receptor in the buffalo prostate

Abstract

The orexins A and B are two peptides discovered initially in the rat lateral hypothalamus involved in the regulation of some body functions such as food intake, sleep/wake cycle, arterial pressure and heart rate. They interact with two receptors defined “orexin receptors 1 and 2”, the first of which shows high selectivity for orexin A and the second binds both the peptides. In this preliminary study the presence of orexin A and orexin 1 receptor in the prostate of the buffalo Bubalus bubalis has been described utilizing the immunohistochemical avidin-biotin technique. The orexin A- and orexin 1 receptor- positive prostatic cells are very numerous and belong to the normal exocrine cytotype which makes up the glandular parenchyma. The role played by orexin A in the genital tract is poorly known. The peptide is retained to stimulate testosterone secretion and to inhibit spermatogonia proliferation in the rat testis.

Keywords

• Orexin A, Orexin 1 receptor, Prostate, Buffalo