Nature Communications (Jun 2018)

Network biology discovers pathogen contact points in host protein-protein interactomes

  • Hadia Ahmed,
  • T. C. Howton,
  • Yali Sun,
  • Natascha Weinberger,
  • Youssef Belkhadir,
  • M. Shahid Mukhtar

DOI
https://doi.org/10.1038/s41467-018-04632-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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Nodes with high centrality in protein–protein interaction (PPI) networks are known to be essential in some organisms. Here, the authors in contrast find that in the interactome of A. thaliana central nodes are enriched in conditional and immune phenotypes and are preferred targets of pathogens.