Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis

Gael Genet; Kevin Boyé; Thomas Mathivet; Roxana Ola; Feng Zhang; Alexandre Dubrac; Jinyu Li; Nafiisha Genet; Luiz Henrique Geraldo; Lorena Benedetti; Steffen Künzel; Laurence Pibouin-Fragner; Jean-Leon Thomas; Anne Eichmann

doi:10.1038/s41467-019-10359-x

Nature Communications (May 2019)

Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis

Gael Genet,
Kevin Boyé,
Thomas Mathivet,
Roxana Ola,
Feng Zhang,
Alexandre Dubrac,
Jinyu Li,
Nafiisha Genet,
Luiz Henrique Geraldo,
Lorena Benedetti,
Steffen Künzel,
Laurence Pibouin-Fragner,
Jean-Leon Thomas,
Anne Eichmann

Affiliations

Gael Genet: Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine
Kevin Boyé: Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine
Thomas Mathivet: Inserm U970, Paris Cardiovascular Research Center
Roxana Ola: Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine
Feng Zhang: Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine
Alexandre Dubrac: Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine
Jinyu Li: Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine
Nafiisha Genet: Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine
Luiz Henrique Geraldo: Inserm U970, Paris Cardiovascular Research Center
Lorena Benedetti: Department of Neuroscience and Cell Biology, School of Medicine, Yale University School of Medicine
Steffen Künzel: Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine
Laurence Pibouin-Fragner: Inserm U970, Paris Cardiovascular Research Center
Jean-Leon Thomas: Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine
Anne Eichmann: Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine

DOI: https://doi.org/10.1038/s41467-019-10359-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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VEGF-A/VEGFR2 signaling is a key driver of endothelial cell migration during sprouting angiogenesis. Here Genet et al. show that endophilin A2 regulates these processes by mediating clathrin-independent VEGFR2 internalization.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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