Understanding the Role of Endothelial Cells in Glioblastoma: Mechanisms and Novel Treatments

Gabrielle Hovis; Neha Chandra; Nidhi Kejriwal; Kaleb Jia-Yi Hsieh; Alison Chu; Isaac Yang; Madhuri Wadehra

doi:10.3390/ijms25116118

International Journal of Molecular Sciences (Jun 2024)

Understanding the Role of Endothelial Cells in Glioblastoma: Mechanisms and Novel Treatments

Gabrielle Hovis,
Neha Chandra,
Nidhi Kejriwal,
Kaleb Jia-Yi Hsieh,
Alison Chu,
Isaac Yang,
Madhuri Wadehra

Affiliations

Gabrielle Hovis: Department of Neurosurgery, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA
Neha Chandra: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA
Nidhi Kejriwal: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA
Kaleb Jia-Yi Hsieh: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA
Alison Chu: Division of Neonatology and Developmental Biology, Department of Pediatrics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA
Isaac Yang: Department of Neurosurgery, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA
Madhuri Wadehra: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA

DOI: https://doi.org/10.3390/ijms25116118
Journal volume & issue: Vol. 25, no. 11
p. 6118

Abstract

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Glioblastoma is a highly aggressive neoplasm and the most common primary malignant brain tumor. Endothelial tissue plays a critical role in glioblastoma growth and progression, facilitating angiogenesis, cellular communication, and tumorigenesis. In this review, we present an up-to-date and comprehensive summary of the role of endothelial cells in glioblastomas, along with an overview of recent developments in glioblastoma therapies and tumor endothelial marker identification.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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