Revista Cubana de Investigaciones Biomédicas (Aug 2020)
Necropic finding of nephroblastoma associated with experimental metabolic syndrome
Abstract
Introduction: The metabolic syndrome presents obesity among its manifestations, which is related to the development of cancer. However, we had not found any cases of malignant neoplasms in animals with metabolic syndrome in four years. Materials and Methods: The experimental biomodel was achieved by the application of a 35% sucrose solution for 20 weeks to 50 weaned male Wistar rats. The diagnosis of nephroblastoma was made by necropsy with morphological observation of the renal lesion. Results: It was detected palpable abdominal mass, after the metabolic syndrome had been confirmed. On macroscopic inspection, a tumor was observed in the lower pole of the right kidney, grayish-brown, hemorrhaging and with cystic changes. Histologically, alterations of a mixed nephroblastoma were observed with blastema, mesenchymal and epithelial components. Conclusions: It is described for the first time, in pathological study the presence of a nephroblastoma case in a rat with experimental metabolic syndrome.
