Nature Communications (Mar 2020)

Multi-level and lineage-specific interactomes of the Hox transcription factor Ubx contribute to its functional specificity

  • Julie Carnesecchi,
  • Gianluca Sigismondo,
  • Katrin Domsch,
  • Clara Eva Paula Baader,
  • Mahmoud-Reza Rafiee,
  • Jeroen Krijgsveld,
  • Ingrid Lohmann

DOI
https://doi.org/10.1038/s41467-020-15223-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

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Many transcription factors regulate gene expression in a lineage- and process-specific manner, despite being expressed in several cell types. Here, the authors show that the Hox transcription factor Ubx has lineage-specific interactomes, which contribute to its cell context-dependent functions.