Frontiers in Neurology (Jul 2019)

Event-Related Desynchronization/Synchronization in Spinocerebellar Ataxia Type 3

  • Yu Aoh,
  • Han-Jun Hsiao,
  • Ming-Kuei Lu,
  • Ming-Kuei Lu,
  • Antonella Macerollo,
  • Hui-Chun Huang,
  • Masashi Hamada,
  • Chon-Haw Tsai,
  • Chon-Haw Tsai,
  • Jui-Cheng Chen,
  • Jui-Cheng Chen,
  • Jui-Cheng Chen

DOI
https://doi.org/10.3389/fneur.2019.00822
Journal volume & issue
Vol. 10

Abstract

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Introduction: Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant, cerebellar degeneration predominant disease caused by excessive CAG repeats. We examined event-related dysynchronization/synchronization (ERD/ERS) in patients with SCA3.Methods: We assessed ERD/ERS of self-paced voluntary hand movements in 15 patients with genetically proven SCA3 in comparison with healthy controls.Results: In ERS, a significant interaction effect between group, frequency, and period (F = 1.591; p = 0.005; ρI = 0.86) was observed. The post-hoc two-tailed independent t-test showed significant differences in high beta and low beta ERS. By contrast, in ERD, no apparent differences were observed in the pattern of patients with SCA3 in comparison with healthy controls (F = 1.01; p = 0.442).Conclusion: The study revealed a decreased ERS in patients with SCA3, especially at the frequency of 20–30 Hz. This study elucidates the significant role of cerebellum in motor control.

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