Nature Communications (Oct 2022)
Decoding the spatial chromatin organization and dynamic epigenetic landscapes of macrophage cells during differentiation and immune activation
- Da Lin,
- Weize Xu,
- Ping Hong,
- Chengchao Wu,
- Zhihui Zhang,
- Siheng Zhang,
- Lingyu Xing,
- Bing Yang,
- Wei Zhou,
- Qin Xiao,
- Jinyue Wang,
- Cong Wang,
- Yu He,
- Xi Chen,
- Xiaojian Cao,
- Jiangwei Man,
- Aikebaier Reheman,
- Xiaofeng Wu,
- Xingjie Hao,
- Zhe Hu,
- Chunli Chen,
- Zimeng Cao,
- Rong Yin,
- Zhen F. Fu,
- Rong Zhou,
- Zhaowei Teng,
- Guoliang Li,
- Gang Cao
Affiliations
- Da Lin
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University
- Weize Xu
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University
- Ping Hong
- National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University
- Chengchao Wu
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University
- Zhihui Zhang
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University
- Siheng Zhang
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University
- Lingyu Xing
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University
- Bing Yang
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University
- Wei Zhou
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University
- Qin Xiao
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University
- Jinyue Wang
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University
- Cong Wang
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University
- Yu He
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University
- Xi Chen
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University
- Xiaojian Cao
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University
- Jiangwei Man
- College of Informatics, Huazhong Agricultural University
- Aikebaier Reheman
- College of Veterinary Medicine, Huazhong Agricultural University
- Xiaofeng Wu
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University
- Xingjie Hao
- School of Public Health, Tongji Medical College, Huazhong University of Science and Technology
- Zhe Hu
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University
- Chunli Chen
- College of Life Science and Technology, Huazhong Agricultural University
- Zimeng Cao
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University
- Rong Yin
- Department of Hematology, Zhongnan Hospital of Wuhan University
- Zhen F. Fu
- Department of Pathology, College of Veterinary Medicine, University of Georgia
- Rong Zhou
- Dapartment of Reproductive Medicine Center, Zhongnan Hospital of Wuhan University
- Zhaowei Teng
- The First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology
- Guoliang Li
- National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University
- Gang Cao
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University
- DOI
- https://doi.org/10.1038/s41467-022-33558-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Here the authors delineate the dynamic changes in 3D genome and epigenome of differentiating macrophages and during infection with Mycobacterium tuberculosis. They reveal a role for NF-κB upon infection and identify SNPs in disease-susceptible loci, including rs1873613 that is located in the anchor of a dynamic chromatin loop.
