Frontiers in Psychiatry (Oct 2019)
Gut Microbiota in Bipolar Depression and Its Relationship to Brain Function: An Advanced Exploration
- Qiaoqiao Lu,
- Qiaoqiao Lu,
- Jianbo Lai,
- Jianbo Lai,
- Jianbo Lai,
- Haifeng Lu,
- Chee Ng,
- Tingting Huang,
- Hua Zhang,
- Kaijing Ding,
- Zheng Wang,
- Zheng Wang,
- Zheng Wang,
- Jiajun Jiang,
- Jianbo Hu,
- Jianbo Hu,
- Jianbo Hu,
- Jing Lu,
- Jing Lu,
- Jing Lu,
- Shaojia Lu,
- Shaojia Lu,
- Shaojia Lu,
- Tingting Mou,
- Tingting Mou,
- Tingting Mou,
- Dandan Wang,
- Dandan Wang,
- Dandan Wang,
- Yanli Du,
- Caixi Xi,
- Hailong Lyu,
- Hailong Lyu,
- Hailong Lyu,
- Jingkai Chen,
- Jingkai Chen,
- Jingkai Chen,
- Yi Xu,
- Yi Xu,
- Yi Xu,
- Zhuhua Liu,
- Shaohua Hu,
- Shaohua Hu,
- Shaohua Hu
Affiliations
- Qiaoqiao Lu
- Department of Psychiatry, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
- Qiaoqiao Lu
- Department of Psychiatry, Hangzhou Seventh People’s Hospital, Hangzhou, China
- Jianbo Lai
- Department of Psychiatry, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
- Jianbo Lai
- The Key Laboratory of Mental Disorder Management of Zhejiang Province, Hangzhou, China
- Jianbo Lai
- Brain Research Institute, Zhejiang University, Hangzhou, China
- Haifeng Lu
- State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Chee Ng
- The Melbourne Clinic, Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia
- Tingting Huang
- Department of Psychiatry, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
- Hua Zhang
- State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Kaijing Ding
- Department of Children and Adolescents’ Psychology, Hangzhou Seventh People’s Hospital, Hangzhou, China
- Zheng Wang
- Department of Psychiatry, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
- Zheng Wang
- The Key Laboratory of Mental Disorder Management of Zhejiang Province, Hangzhou, China
- Zheng Wang
- Brain Research Institute, Zhejiang University, Hangzhou, China
- Jiajun Jiang
- Department of Psychiatry, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
- Jianbo Hu
- Department of Psychiatry, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
- Jianbo Hu
- The Key Laboratory of Mental Disorder Management of Zhejiang Province, Hangzhou, China
- Jianbo Hu
- Brain Research Institute, Zhejiang University, Hangzhou, China
- Jing Lu
- Department of Psychiatry, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
- Jing Lu
- The Key Laboratory of Mental Disorder Management of Zhejiang Province, Hangzhou, China
- Jing Lu
- Brain Research Institute, Zhejiang University, Hangzhou, China
- Shaojia Lu
- Department of Psychiatry, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
- Shaojia Lu
- The Key Laboratory of Mental Disorder Management of Zhejiang Province, Hangzhou, China
- Shaojia Lu
- Brain Research Institute, Zhejiang University, Hangzhou, China
- Tingting Mou
- Department of Psychiatry, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
- Tingting Mou
- The Key Laboratory of Mental Disorder Management of Zhejiang Province, Hangzhou, China
- Tingting Mou
- Brain Research Institute, Zhejiang University, Hangzhou, China
- Dandan Wang
- Department of Psychiatry, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
- Dandan Wang
- The Key Laboratory of Mental Disorder Management of Zhejiang Province, Hangzhou, China
- Dandan Wang
- Brain Research Institute, Zhejiang University, Hangzhou, China
- Yanli Du
- Department of Psychiatry, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
- Caixi Xi
- Department of Psychiatry, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
- Hailong Lyu
- Department of Psychiatry, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
- Hailong Lyu
- The Key Laboratory of Mental Disorder Management of Zhejiang Province, Hangzhou, China
- Hailong Lyu
- Brain Research Institute, Zhejiang University, Hangzhou, China
- Jingkai Chen
- Department of Psychiatry, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
- Jingkai Chen
- The Key Laboratory of Mental Disorder Management of Zhejiang Province, Hangzhou, China
- Jingkai Chen
- Brain Research Institute, Zhejiang University, Hangzhou, China
- Yi Xu
- Department of Psychiatry, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
- Yi Xu
- The Key Laboratory of Mental Disorder Management of Zhejiang Province, Hangzhou, China
- Yi Xu
- Brain Research Institute, Zhejiang University, Hangzhou, China
- Zhuhua Liu
- Center of Mental Health, General Hospital of Ningxia Medical University, Yinchuan, China
- Shaohua Hu
- Department of Psychiatry, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
- Shaohua Hu
- The Key Laboratory of Mental Disorder Management of Zhejiang Province, Hangzhou, China
- Shaohua Hu
- Brain Research Institute, Zhejiang University, Hangzhou, China
- DOI
- https://doi.org/10.3389/fpsyt.2019.00784
- Journal volume & issue
-
Vol. 10
Abstract
The mechanism of bipolar disorder is unclear. Growing evidence indicates that gut microbiota plays a pivotal role in mental disorders. This study aimed to find out changes in the gut microbiota in bipolar depression (BD) subjects following treatment with quetiapine and evaluate their correlations with the brain and immune function. Totally 36 subjects with BD and 27 healthy controls (HCs) were recruited. The severity of depression was evaluated with the Montgomery-Asberg depression rating scale (MADRS). At baseline, fecal samples were collected and analyzed by quantitative polymerase chain reaction (qPCR). T lymphocyte subsets were measured to examine immune function. Near-infrared spectroscopy (NIRS) was used to assess brain function. All BD subjects received quetiapine treatment (300 mg/d) for four weeks, following which the fecal microbiota and immune profiles were reexamined. Here, we first put forward the new concept of brain-gut coefficient of balance (B-GCB), which referred to the ratio of [oxygenated hemoglobin]/(Bifidobacteria to Enterobacteriaceae ratio), to analyze the linkage between the gut microbiota and brain function. At baseline, the CD3+ T cell proportion was positively correlated with log10 Enterobacter spp count, whereas the correlativity between the other bacteria and immune profiles were negative. Log10 B-GCB was positively correlated with CD3+ T cell proportion. In subjects with BD, counts of Faecalibacterium prausnitzii, Bacteroides–Prevotella group, Atopobium Cluster, Enterobacter spp, and Clostridium Cluster IV were higher, whereas the log10 (B/E) were lower than HCs (B/E refers to Bifidobacteria to Enterobacteriaceae ratio and represents microbial colonization resistance). After treatment, MADRS scores were reduced, whereas the levels of Eubacterium rectale, Bifidobacteria, and B/E increased. The composition of the gut microbiota and its relationship to brain function were altered in BD subjects. Quetiapine treatment was effective for depression and influenced the composition of gut microbiota in patients.Clinical Trial Registration:http://www.chictr.org.cn/index.aspx, identifier ChiCTR-COC-17011401, URL: http://www.chictr.org.cn/listbycreater.aspx.
Keywords
