Nature Communications (Jul 2019)

JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma

  • Matthew Wong,
  • Yuting Sun,
  • Zhichao Xi,
  • Giorgio Milazzo,
  • Rebecca C. Poulos,
  • Christoph Bartenhagen,
  • Jessica L. Bell,
  • Chelsea Mayoh,
  • Nicholas Ho,
  • Andrew E. Tee,
  • Xiaoqiong Chen,
  • Yang Li,
  • Roberto Ciaccio,
  • Pei Y. Liu,
  • Chen C. Jiang,
  • Qing Lan,
  • Nisitha Jayatilleke,
  • Belamy B. Cheung,
  • Michelle Haber,
  • Murray D. Norris,
  • Xu D. Zhang,
  • Glenn M. Marshall,
  • Jenny Y. Wang,
  • Stefan Hüttelmaier,
  • Matthias Fischer,
  • Jason W. H. Wong,
  • Hongxi Xu,
  • Giovanni Perini,
  • Qihan Dong,
  • Rani E. George,
  • Tao Liu

DOI
https://doi.org/10.1038/s41467-019-11132-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

Read online

Although the gain in chromosome 17q21-ter is commonly associated with neuroblastoma, it is not clear which gene of this region mediates tumorigenesis. Here, the authors are showing that JMJD6, which locates in that region, is a neuroblastoma tumorigenic factor.