Research progress on mitochondrial mechanisms of sensitivity to inhalational anesthetics

Abstract

Experimental animals and people have different sensitivity to inhalational anesthetics, which is related to the depth of anesthesia during general anesthesia and the perioperative safety of patients. Studying the mechanism of inhalational anesthetics sensitivity is helpful to improve the postoperative outcomes of patients. Mitochondria are important organelles for energy metabolism in the body, and changes in mitochondrial structure and function are involved in the mechanism of inhalational anesthetics sensitivity. Current research indicates that mitochondrial related gene mutations, metabolic pathways, ion channels, and other factors are involved in the mechanism of inhalational anesthetics sensitivity. In view of this, this article reviews the research progress in several aspects such as inhalational anesthetics sensitivity overview, mitochondrial related gene mutations, metabolic pathways, ion channels, etc.

Keywords

• inhalational anesthetics， mitochondria， sensitivity， energy metabolism