Communications Biology (May 2021)
Iron induces two distinct Ca2+ signalling cascades in astrocytes
- Wenzheng Guan,
- Maosheng Xia,
- Ming Ji,
- Beina Chen,
- Shuai Li,
- Manman Zhang,
- Shanshan Liang,
- Binjie Chen,
- Wenliang Gong,
- Chengyi Dong,
- Gehua Wen,
- Xiaoni Zhan,
- Dianjun Zhang,
- Xinyu Li,
- Yuefei Zhou,
- Dawei Guan,
- Alexei Verkhratsky,
- Baoman Li
Affiliations
- Wenzheng Guan
- Practical Teaching Centre, School of Forensic Medicine, China Medical University
- Maosheng Xia
- Practical Teaching Centre, School of Forensic Medicine, China Medical University
- Ming Ji
- Practical Teaching Centre, School of Forensic Medicine, China Medical University
- Beina Chen
- Practical Teaching Centre, School of Forensic Medicine, China Medical University
- Shuai Li
- Practical Teaching Centre, School of Forensic Medicine, China Medical University
- Manman Zhang
- Practical Teaching Centre, School of Forensic Medicine, China Medical University
- Shanshan Liang
- Practical Teaching Centre, School of Forensic Medicine, China Medical University
- Binjie Chen
- Practical Teaching Centre, School of Forensic Medicine, China Medical University
- Wenliang Gong
- Practical Teaching Centre, School of Forensic Medicine, China Medical University
- Chengyi Dong
- Department of Orthopaedics, The First Hospital, China Medical University
- Gehua Wen
- Practical Teaching Centre, School of Forensic Medicine, China Medical University
- Xiaoni Zhan
- Practical Teaching Centre, School of Forensic Medicine, China Medical University
- Dianjun Zhang
- Practical Teaching Centre, School of Forensic Medicine, China Medical University
- Xinyu Li
- Practical Teaching Centre, School of Forensic Medicine, China Medical University
- Yuefei Zhou
- Department of Orthopaedics, The First Hospital, China Medical University
- Dawei Guan
- Department of Forensic Pathology, School of Forensic Medicine, China Medical University
- Alexei Verkhratsky
- Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University
- Baoman Li
- Practical Teaching Centre, School of Forensic Medicine, China Medical University
- DOI
- https://doi.org/10.1038/s42003-021-02060-x
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 13
Abstract
Wenzheng Guan and Maosheng Xia et al. use a combination of pharmacological, genetic, and calcium imaging approaches to describe two mechanisms of iron-induced astrocytic calcium signaling. Altogether, these results suggest that astrocytes may act as a barrier to excessive iron in the brain, thereby improving our understanding of the role of astrocytes in normal neurodevelopment.
