Nature Communications (Jul 2017)
Transancestral mapping and genetic load in systemic lupus erythematosus
- Carl D. Langefeld,
- Hannah C. Ainsworth,
- Deborah S. Cunninghame Graham,
- Jennifer A. Kelly,
- Mary E. Comeau,
- Miranda C. Marion,
- Timothy D. Howard,
- Paula S. Ramos,
- Jennifer A. Croker,
- David L. Morris,
- Johanna K. Sandling,
- Jonas Carlsson Almlöf,
- Eduardo M. Acevedo-Vásquez,
- Graciela S. Alarcón,
- Alejandra M. Babini,
- Vicente Baca,
- Anders A. Bengtsson,
- Guillermo A. Berbotto,
- Marc Bijl,
- Elizabeth E. Brown,
- Hermine I. Brunner,
- Mario H. Cardiel,
- Luis Catoggio,
- Ricard Cervera,
- Jorge M. Cucho-Venegas,
- Solbritt Rantapää Dahlqvist,
- Sandra D’Alfonso,
- Berta Martins Da Silva,
- Iñigo de la Rúa Figueroa,
- Andrea Doria,
- Jeffrey C. Edberg,
- Emőke Endreffy,
- Jorge A. Esquivel-Valerio,
- Paul R. Fortin,
- Barry I. Freedman,
- Johan Frostegård,
- Mercedes A. García,
- Ignacio García de la Torre,
- Gary S. Gilkeson,
- Dafna D. Gladman,
- Iva Gunnarsson,
- Joel M. Guthridge,
- Jennifer L. Huggins,
- Judith A. James,
- Cees G. M. Kallenberg,
- Diane L. Kamen,
- David R. Karp,
- Kenneth M. Kaufman,
- Leah C. Kottyan,
- László Kovács,
- Helle Laustrup,
- Bernard R. Lauwerys,
- Quan-Zhen Li,
- Marco A. Maradiaga-Ceceña,
- Javier Martín,
- Joseph M. McCune,
- David R. McWilliams,
- Joan T. Merrill,
- Pedro Miranda,
- José F. Moctezuma,
- Swapan K. Nath,
- Timothy B. Niewold,
- Lorena Orozco,
- Norberto Ortego-Centeno,
- Michelle Petri,
- Christian A. Pineau,
- Bernardo A. Pons-Estel,
- Janet Pope,
- Prithvi Raj,
- Rosalind Ramsey-Goldman,
- John D. Reveille,
- Laurie P. Russell,
- José M. Sabio,
- Carlos A. Aguilar-Salinas,
- Hugo R. Scherbarth,
- Raffaella Scorza,
- Michael F. Seldin,
- Christopher Sjöwall,
- Elisabet Svenungsson,
- Susan D. Thompson,
- Sergio M. A. Toloza,
- Lennart Truedsson,
- Teresa Tusié-Luna,
- Carlos Vasconcelos,
- Luis M. Vilá,
- Daniel J. Wallace,
- Michael H. Weisman,
- Joan E. Wither,
- Tushar Bhangale,
- Jorge R. Oksenberg,
- John D. Rioux,
- Peter K. Gregersen,
- Ann-Christine Syvänen,
- Lars Rönnblom,
- Lindsey A. Criswell,
- Chaim O. Jacob,
- Kathy L. Sivils,
- Betty P. Tsao,
- Laura E. Schanberg,
- Timothy W. Behrens,
- Earl D. Silverman,
- Marta E. Alarcón-Riquelme,
- Robert P. Kimberly,
- John B. Harley,
- Edward K. Wakeland,
- Robert R. Graham,
- Patrick M. Gaffney,
- Timothy J. Vyse
Affiliations
- Carl D. Langefeld
- Center for Public Health Genomics, Wake Forest School of Medicine
- Hannah C. Ainsworth
- Center for Public Health Genomics, Wake Forest School of Medicine
- Deborah S. Cunninghame Graham
- Divisions of Genetics and Molecular Medicine and Immunology, Infection and Inflammatory Diseases, King’s College London, Guy’s Hospital
- Jennifer A. Kelly
- Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation
- Mary E. Comeau
- Center for Public Health Genomics, Wake Forest School of Medicine
- Miranda C. Marion
- Center for Public Health Genomics, Wake Forest School of Medicine
- Timothy D. Howard
- Center for Public Health Genomics, Wake Forest School of Medicine
- Paula S. Ramos
- Department of Public Health Sciences, Medical University of South Carolina
- Jennifer A. Croker
- Division of Clinical Immunology and Rheumatology, UAB School of Medicine
- David L. Morris
- Divisions of Genetics and Molecular Medicine and Immunology, Infection and Inflammatory Diseases, King’s College London, Guy’s Hospital
- Johanna K. Sandling
- Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University
- Jonas Carlsson Almlöf
- Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University
- Eduardo M. Acevedo-Vásquez
- Departamento de Reumatología, Hospital G. Almenara y Facultad de Medicina, Universidad Nacional Mayor de San Marcos
- Graciela S. Alarcón
- Division of Clinical Immunology and Rheumatology, UAB School of Medicine
- Alejandra M. Babini
- Hospital Italiano de Córdoba
- Vicente Baca
- Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social
- Anders A. Bengtsson
- Department of Clinical Sciences, Rheumatology, Lund University
- Guillermo A. Berbotto
- Hospital Eva Perón
- Marc Bijl
- Department of Internal Medicine and Rheumatology, Martini Hospital
- Elizabeth E. Brown
- Division of Clinical Immunology and Rheumatology, UAB School of Medicine
- Hermine I. Brunner
- Division of Rheumatology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati
- Mario H. Cardiel
- Centro de Investigación Clínica de Morelia
- Luis Catoggio
- Hospital Italiano de Buenos Aires
- Ricard Cervera
- Department of Autoimmune Diseases, Hospital Clínic, University of Barcelona
- Jorge M. Cucho-Venegas
- Departamento de Reumatología, Hospital G. Almenara y Facultad de Medicina, Universidad Nacional Mayor de San Marcos
- Solbritt Rantapää Dahlqvist
- Department of Public Health and Clinical Medicine, Division of Rheumatology, Umeå University
- Sandra D’Alfonso
- Department of Health Sciences and Institute of Research in Autoimmune Diseases (IRCAD), University of Eastern Piedmont
- Berta Martins Da Silva
- Unidade Multidisciplinar em Investigação Biomédica/Instituto de Ciências Biomédicas de Abel Salazar—Universidade do Porto
- Iñigo de la Rúa Figueroa
- Department of Rheumatology, Hospital Universitario de Gran Canaria Dr Negrín
- Andrea Doria
- Division of Rheumatology, Department of Medicine (DIMED), University of Padua
- Jeffrey C. Edberg
- Division of Clinical Immunology and Rheumatology, UAB School of Medicine
- Emőke Endreffy
- Department of Pediatrics and Child Health Center, Albert Szent-Györgyi Medical Center, Faculty of Medicine, University of Szeged
- Jorge A. Esquivel-Valerio
- Hospital Universitario ‘Dr José Eleuterio González’ Universidad Autonoma de Nuevo León
- Paul R. Fortin
- CHU de Québec Université Laval
- Barry I. Freedman
- Center for Public Health Genomics, Wake Forest School of Medicine
- Johan Frostegård
- Institute of Environmental Medicine, Unit of Immunology and Chronic diseases, Karolinska Institutet
- Mercedes A. García
- Division of Rheumatology, Hospital Interzonal General de Agudos General San Martín
- Ignacio García de la Torre
- Departamento de Fisiología, University of Guadalajara
- Gary S. Gilkeson
- Department of Medicine, Medical University of South Carolina
- Dafna D. Gladman
- Centre for Prognosis Studies in The Rheumatic Diseases, Krembil Research Institute, Toronto Western Hospital
- Iva Gunnarsson
- Department of Medicine Solna, Unit of Rheumatology, Karolinska Institutet, Karolinska University Hospital
- Joel M. Guthridge
- Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation
- Jennifer L. Huggins
- Division of Rheumatology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati
- Judith A. James
- Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation
- Cees G. M. Kallenberg
- Department of Rheumatology and Clinical Immunology,University Medical Center Groningen,University of Groningen
- Diane L. Kamen
- Department of Medicine, Medical University of South Carolina
- David R. Karp
- Department of Immunology, University of Texas SouthWestern Medical Center
- Kenneth M. Kaufman
- Department of Pediatrics, Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center
- Leah C. Kottyan
- Department of Pediatrics, Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center
- László Kovács
- Department of Rheumatology, Albert Szent-Györgyi Medical Centre, University of Szeged
- Helle Laustrup
- Department of Rheumatology, Odense University Hospital
- Bernard R. Lauwerys
- Rheumatology, Cliniques Universitaires Saint-Luc & Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain
- Quan-Zhen Li
- Department of Immunology, University of Texas SouthWestern Medical Center
- Marco A. Maradiaga-Ceceña
- Hospital General de Culiacán
- Javier Martín
- Instituto de Parasitología y Biomedicina López Neyra, CSIC
- Joseph M. McCune
- University of Michigan Medical Center
- David R. McWilliams
- Center for Public Health Genomics, Wake Forest School of Medicine
- Joan T. Merrill
- Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation
- Pedro Miranda
- Centro de Estudios Reumatológicos, Santiago de Chile
- José F. Moctezuma
- Departamento de Reumatología, Hospital General de México
- Swapan K. Nath
- Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation
- Timothy B. Niewold
- Department of Rheumatology, Mayo Clinic
- Lorena Orozco
- Instituto Nacional de Medicina Genómica (INMEGEN)
- Norberto Ortego-Centeno
- Unidad de Enfermedades Autoimmunes Sistémicas, UGC Medicina Interna, Hospital Universitario San Cecilio
- Michelle Petri
- Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine
- Christian A. Pineau
- Rheumatology Division, McGill University
- Bernardo A. Pons-Estel
- Department of Rheumatology, Sanatorio Parque
- Janet Pope
- University of Western Ontario
- Prithvi Raj
- Department of Immunology, University of Texas SouthWestern Medical Center
- Rosalind Ramsey-Goldman
- Division of Rheumatology, Northwestern University Feinberg School of Medicine
- John D. Reveille
- The University of Texas Health Science Center at Houston (UTHealth) Medical School
- Laurie P. Russell
- Center for Public Health Genomics, Wake Forest School of Medicine
- José M. Sabio
- Hospital Universitario Virgen de las Nieves
- Carlos A. Aguilar-Salinas
- Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición
- Hugo R. Scherbarth
- Unidad Reumatología y Enfermedades Autoinmunes H.I.G.A. Dr Alende Mar del Plata
- Raffaella Scorza
- Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca'Granda Ospedale Ma Repiore Policlinico and University of Milan
- Michael F. Seldin
- Department of Biochemistry and Molecular Medicine, UC Davis School of Medicine
- Christopher Sjöwall
- Rheumatology Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine, Linköping University
- Elisabet Svenungsson
- Department of Medicine Solna, Unit of Rheumatology, Karolinska Institutet, Karolinska University Hospital
- Susan D. Thompson
- Department of Pediatrics, Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center
- Sergio M. A. Toloza
- Ministry of Health, San Fernando del Valle de Catamarca
- Lennart Truedsson
- Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University
- Teresa Tusié-Luna
- Unidad de Biología Molecular y Medicina Genómica Instituto de Investigaciones Biomédicas/UNAM Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
- Carlos Vasconcelos
- Hospital Santo Antonio, Universidade do Porto
- Luis M. Vilá
- University of Puerto Rico School of Medicine
- Daniel J. Wallace
- Department of Medicine, Cedars Sinai Medical Center
- Michael H. Weisman
- Department of Medicine, Cedars Sinai Medical Center
- Joan E. Wither
- Centre for Prognosis Studies in The Rheumatic Diseases, Krembil Research Institute, Toronto Western Hospital
- Tushar Bhangale
- Human Genetics, Genentech Inc, South San Francisco
- Jorge R. Oksenberg
- Department of Neurology and Institute of Human Genetics, University of California at San Francisco
- John D. Rioux
- Université de Montréal and the Montreal Heart Institute
- Peter K. Gregersen
- Center for Genomics & Human Genetics, The Feinstein Institute for Medical Research
- Ann-Christine Syvänen
- Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University
- Lars Rönnblom
- Department of Medical Sciences, Rheumatology, Uppsala University
- Lindsey A. Criswell
- Division of Rheumatology, Rosalind Russell/Ephraim P Engleman Rheumatology Research Center, UCSF School of Medicine
- Chaim O. Jacob
- Keck School of Medicine of USC
- Kathy L. Sivils
- Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation
- Betty P. Tsao
- Department of Medicine, Medical University of South Carolina
- Laura E. Schanberg
- Department of Pediatrics, Duke University
- Timothy W. Behrens
- Human Genetics, Genentech Inc, South San Francisco
- Earl D. Silverman
- Department of Pediatrics and the Institute of Medical Sciences, The Hospital for Sick Children, Hospital for Sick Children Research Institute and University of Toronto
- Marta E. Alarcón-Riquelme
- Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation
- Robert P. Kimberly
- Division of Clinical Immunology and Rheumatology, UAB School of Medicine
- John B. Harley
- Department of Pediatrics, Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center
- Edward K. Wakeland
- Department of Immunology, University of Texas SouthWestern Medical Center
- Robert R. Graham
- Human Genetics, Genentech Inc, South San Francisco
- Patrick M. Gaffney
- Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation
- Timothy J. Vyse
- Divisions of Genetics and Molecular Medicine and Immunology, Infection and Inflammatory Diseases, King’s College London, Guy’s Hospital
- DOI
- https://doi.org/10.1038/ncomms16021
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 18
Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong ethnic and gender bias. In a transancestral genetic association study, Langefeldet al. identify 24 novel regions associated with risk to lupus and propose a cumulative hits hypothesis for loci conferring risk to SLE.
