Nature Communications (Jan 2020)
TGF-β induces ST2 and programs ILC2 development
- Li Wang,
- Jun Tang,
- Xia Yang,
- Peter Zanvit,
- Kairong Cui,
- Wai Lim Ku,
- Wenwen Jin,
- Dunfang Zhang,
- Nathan Goldberg,
- Alexander Cain,
- Bing Ni,
- Keji Zhao,
- Yuzhang Wu,
- WanJun Chen
Affiliations
- Li Wang
- Mucosal Immunology Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH)
- Jun Tang
- Mucosal Immunology Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH)
- Xia Yang
- Mucosal Immunology Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH)
- Peter Zanvit
- Mucosal Immunology Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH)
- Kairong Cui
- Center for System Biology, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH)
- Wai Lim Ku
- Center for System Biology, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH)
- Wenwen Jin
- Mucosal Immunology Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH)
- Dunfang Zhang
- Mucosal Immunology Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH)
- Nathan Goldberg
- Mucosal Immunology Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH)
- Alexander Cain
- Mucosal Immunology Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH)
- Bing Ni
- Institute of Immunology PLA & Department of Immunology, Third Military Medical University
- Keji Zhao
- Center for System Biology, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH)
- Yuzhang Wu
- Institute of Immunology PLA & Department of Immunology, Third Military Medical University
- WanJun Chen
- Mucosal Immunology Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH)
- DOI
- https://doi.org/10.1038/s41467-019-13734-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
TGF-β is thought to be important for group 2 innate lymphoid cell (ILC2) function. Here the authors show that TGF-β drives expression of ST2 specifically in ILC2 progenitors and thereby is also important for the development of ILC2s in the bone marrow.
