RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection

Amy E. L. Stone; Richard Green; Courtney Wilkins; Emily A. Hemann; Michael Gale

doi:10.1038/s41467-019-11250-5

Nature Communications (Aug 2019)

RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection

Amy E. L. Stone,
Richard Green,
Courtney Wilkins,
Emily A. Hemann,
Michael Gale

Affiliations

Amy E. L. Stone: Department of Immunology and Center for Innate Immunity and Immune Disease, University of Washington
Richard Green: Department of Immunology and Center for Innate Immunity and Immune Disease, University of Washington
Courtney Wilkins: Department of Immunology and Center for Innate Immunity and Immune Disease, University of Washington
Emily A. Hemann: Department of Immunology and Center for Innate Immunity and Immune Disease, University of Washington
Michael Gale: Department of Immunology and Center for Innate Immunity and Immune Disease, University of Washington

DOI: https://doi.org/10.1038/s41467-019-11250-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

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RIG-I- like receptors (RLRs) play an important role in immune defense against West Nile virus (WNV). Here, using a systems biology approach, the authors show that macrophage polarization to a proinflammatory M1 phenotype via RIG-I and MDA5 signaling is critical for innate immune control in WNV-infected mouse tissues.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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