Transcriptional changes in the mammary gland during lactation revealed by single cell sequencing of cells from human milk

Alecia-Jane Twigger; Lisa K. Engelbrecht; Karsten Bach; Isabel Schultz-Pernice; Sara Pensa; Jack Stenning; Stefania Petricca; Christina H. Scheel; Walid T. Khaled

doi:10.1038/s41467-021-27895-0

Nature Communications (Jan 2022)

Transcriptional changes in the mammary gland during lactation revealed by single cell sequencing of cells from human milk

Alecia-Jane Twigger,
Lisa K. Engelbrecht,
Karsten Bach,
Isabel Schultz-Pernice,
Sara Pensa,
Jack Stenning,
Stefania Petricca,
Christina H. Scheel,
Walid T. Khaled

Affiliations

Alecia-Jane Twigger: Department of Pharmacology, University of Cambridge
Lisa K. Engelbrecht: Institute of Stem Cell Research, Helmholtz Zentrum München
Karsten Bach: Department of Pharmacology, University of Cambridge
Isabel Schultz-Pernice: Institute of Stem Cell Research, Helmholtz Zentrum München
Sara Pensa: Department of Pharmacology, University of Cambridge
Jack Stenning: Department of Pharmacology, University of Cambridge
Stefania Petricca: Institute of Stem Cell Research, Helmholtz Zentrum München
Christina H. Scheel: Institute of Stem Cell Research, Helmholtz Zentrum München
Walid T. Khaled: Department of Pharmacology, University of Cambridge

DOI: https://doi.org/10.1038/s41467-021-27895-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Human mammary tissue remodelling that takes place during pregnancy and lactation remains poorly understood. Here the authors characterize cells in human milk, identifying epithelial cells resembling luminal progenitors and immune cells, contributing insights into this process.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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