Nature Communications (Nov 2021)

Age-seroprevalence curves for the multi-strain structure of influenza A virus

  • Dao Nguyen Vinh,
  • Nguyen Thi Duy Nhat,
  • Erwin de Bruin,
  • Nguyen Ha Thao Vy,
  • Tran Thi Nhu Thao,
  • Huynh Thi Phuong,
  • Pham Hong Anh,
  • Stacy Todd,
  • Tran Minh Quan,
  • Nguyen Thi Le Thanh,
  • Nguyen Thi Nam Lien,
  • Nguyen Thi Hong Ha,
  • Tran Thi Kim Hong,
  • Pham Quang Thai,
  • Marc Choisy,
  • Tran Dang Nguyen,
  • Cameron P. Simmons,
  • Guy E. Thwaites,
  • Hannah E. Clapham,
  • Nguyen Van Vinh Chau,
  • Marion Koopmans,
  • Maciej F. Boni

DOI
https://doi.org/10.1038/s41467-021-26948-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 9

Abstract

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Multi-strain pathogens, such as influenza, present challenges for interpretation of seroprevalence data as estimates may vary by strain. Here, the authors develop a method for estimating age-specific seroprevalence based on principal components analysis and apply it to influenza data from Vietnam.