Nature Communications (Jan 2023)
Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection
- Shun Li,
- Florian olde Heuvel,
- Rida Rehman,
- Oumayma Aousji,
- Albrecht Froehlich,
- Zhenghui Li,
- Rebecca Jark,
- Wanhong Zhang,
- Alison Conquest,
- Sarah Woelfle,
- Michael Schoen,
- Caitlin C. O´Meara,
- Richard Lee Reinhardt,
- David Voehringer,
- Jan Kassubek,
- Albert Ludolph,
- Markus Huber-Lang,
- Bernd Knöll,
- Maria Cristina Morganti-Kossmann,
- Marisa M. Brockmann,
- Tobias Boeckers,
- Francesco Roselli
Affiliations
- Shun Li
- Department of Neurology, Ulm University
- Florian olde Heuvel
- Department of Neurology, Ulm University
- Rida Rehman
- Department of Neurology, Ulm University
- Oumayma Aousji
- Department of Neurology, Ulm University
- Albrecht Froehlich
- Department of Neurology, Ulm University
- Zhenghui Li
- Department of Neurology, Ulm University
- Rebecca Jark
- Centre for Molecular Neurobiology Hamburg, University Medical Centre Hamburg-Eppendorf
- Wanhong Zhang
- Department of Neurosurgery, Kaifeng central Hospital
- Alison Conquest
- National Trauma Research Institute and Department of Neurosurgery, TheAlfred Hospital
- Sarah Woelfle
- Institute of Anatomy and Cell Biology, Ulm University
- Michael Schoen
- Institute of Anatomy and Cell Biology, Ulm University
- Caitlin C. O´Meara
- Cardiovascular Centre, Medical College of Wisconsin
- Richard Lee Reinhardt
- Department of Immunology and Microbiology, University of Colorado Medical School
- David Voehringer
- Department of Infection Biology, Friedrich-Alexander University Erlangen-Nuremberg (FAU)
- Jan Kassubek
- Department of Neurology, Ulm University
- Albert Ludolph
- Department of Neurology, Ulm University
- Markus Huber-Lang
- Institute of Clinical and Experimental Trauma Immunology, Ulm University
- Bernd Knöll
- Institute of Neurobiochemistry, Ulm University
- Maria Cristina Morganti-Kossmann
- National Trauma Research Institute and Department of Neurosurgery, TheAlfred Hospital
- Marisa M. Brockmann
- Centre for Molecular Neurobiology Hamburg, University Medical Centre Hamburg-Eppendorf
- Tobias Boeckers
- Institute of Anatomy and Cell Biology, Ulm University
- Francesco Roselli
- Department of Neurology, Ulm University
- DOI
- https://doi.org/10.1038/s41467-023-35806-8
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 21
Abstract
Il-13 is expressed in neurons and IL-13 ko causes memory impairment. Here, authors show that IL-13 and its receptor IL-13Ra1 are pre- and post-synaptic proteins, respectively, involved in synaptic signaling, plasticity and neuroprotection.
