Carbon dots nanozyme for anti-inflammatory therapy via scavenging intracellular reactive oxygen species

Chen Dong; Chen Dong; Xuehua Ma; Yi Huang; Yujie Zhang; Xiang Gao

doi:10.3389/fbioe.2022.943399

Frontiers in Bioengineering and Biotechnology (Aug 2022)

Carbon dots nanozyme for anti-inflammatory therapy via scavenging intracellular reactive oxygen species

Chen Dong,
Chen Dong,
Xuehua Ma,
Yi Huang,
Yujie Zhang,
Xiang Gao

Affiliations

Chen Dong: Department of Neurosurgery, Ningbo First Hospital, Ningbo Hospital of Zhejiang University, Ningbo, China
Chen Dong: CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, China
Xuehua Ma: CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, China
Yi Huang: Department of Neurosurgery, Ningbo First Hospital, Ningbo Hospital of Zhejiang University, Ningbo, China
Yujie Zhang: CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, China
Xiang Gao: Department of Neurosurgery, Ningbo First Hospital, Ningbo Hospital of Zhejiang University, Ningbo, China

DOI: https://doi.org/10.3389/fbioe.2022.943399
Journal volume & issue: Vol. 10

Abstract

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Developing an efficient antioxidant for anti-inflammatory therapy via scavenging reactive oxygen species (ROS) remains a great challenge owing to the insufficient activity and stability of traditional antioxidants. Herein, we explored and simply synthesized a biocompatible carbon dots (CDs) nanozyme with excellent scavenging activity of ROS for anti-inflammatory therapy. As expected, CDs nanozyme effectively eliminate many kinds of free radicals including •OH, O2•−, and ABTS+•. Benefiting from multienzyme activities against ROS, CDs nanozyme can decrease the levels of pro-inflammatory cytokines, resulting in good anti-inflammatory effect. Taken together, this study not only sheds light on design of bioactive antioxidants but also broadens the biomedical application of CDs in the treatment of inflammation.

Published in Frontiers in Bioengineering and Biotechnology

ISSN: 2296-4185 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Technology: Chemical technology: Biotechnology
Website: http://www.frontiersin.org/bioengineering_and_biotechnology

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