Терапевтический архив (Jan 2003)
Efficacy of anti-inflammatory treatment with benacort of patients with chronic obstructive pulmonary disease in exacerbation
Abstract
Aim. To determine a course and prognostic effectiveness of corticosteroid therapy of chronic obstructive pulmonary disease (COPD). Material and methods. Long-term therapy with broncholytics (berodual) and benacort was given to 25 patients in non-infectious exacerbation, 20 patients received broncholitics of 45 COPD patients with mild and moderate ventilation disorders. Follow-up lasted for 2.5 years. Treatment effectiveness was judged by clinical indices, external respiration function, parameters of systemic immunity, cyto- gram of induced sputum and concentration of inflammatory markers in the sputum. Results. An immediate effect of two-month therapy with benacort of COPD exacerbations manifested with positive clinical dynamics and relief of endobronchial inflammation. Prognostic efficacy - with a significant reduction of the frequency of COPD exacerbations and of their mean duration more than 3-fold. Conclusion. The results of long-term follow-up support validity of inhalation corticosteroids use for eradication and prevention of noninfectious exacerbations of COPD.
