Various synthesis and biological evaluation of some tri -tetra-substituted imidazoles derivatives: A review
Abdeljalil Hamdi,
Walid Daoudi,
Mohamed Aaddouz,
Mohamed Azzouzi,
Hassan Amhamdi,
Abdellah Elyoussfi,
Abdelmalik El Aatiaoui,
Dakeshwar Kumar Verma,
Mohamed Abboud,
M'hamed Ahari
Affiliations
Abdeljalil Hamdi
Applied Chemistry Research Unit, FSTH, Abdelmalek Essaâdi University, AL Hoceima, Tetouan, Morocco
Walid Daoudi
Laboratory of Molecular Chemistry, Materials and Environment (LCM2E), Departement of Chemistry, Multidisciplinary Faculty of Nador, University Mohamed I, 60700 Nador, Morocco; Corresponding author.
Mohamed Aaddouz
Laboratoire de chimie analytique appliquée, matériaux et environnement (LC2AME), Faculté des Sciences, B.P. 717, 60000 Oujda, Morocco
Mohamed Azzouzi
Laboratory of Molecular Chemistry, Materials and Environment (LCM2E), Departement of Chemistry, Multidisciplinary Faculty of Nador, University Mohamed I, 60700 Nador, Morocco
Hassan Amhamdi
Applied Chemistry Research Unit, FSTH, Abdelmalek Essaâdi University, AL Hoceima, Tetouan, Morocco
Abdellah Elyoussfi
Laboratoire de chimie analytique appliquée, matériaux et environnement (LC2AME), Faculté des Sciences, B.P. 717, 60000 Oujda, Morocco
Abdelmalik El Aatiaoui
Laboratory of Molecular Chemistry, Materials and Environment (LCM2E), Departement of Chemistry, Multidisciplinary Faculty of Nador, University Mohamed I, 60700 Nador, Morocco
Dakeshwar Kumar Verma
Department of Chemistry, Government Digvijay Autonomous Postgraduate College, Rajnandgaon, Chhattisgarh-491441, India
Mohamed Abboud
Catalysis Research Group (CRG), Department of Chemistry, College of Science, King Khalid University, Abha 61413, Saudi Arabia; Corresponding author.
M'hamed Ahari
Applied Chemistry Research Unit, FSTH, Abdelmalek Essaâdi University, AL Hoceima, Tetouan, Morocco
The imidazole nucleus represents a significant group of heterocyclic molecules with diverse significance in the modern world due to its exploration potential and various pharmacological applications. The relevance of imidazole and its derivatives has gained popularity in recent years, especially in the production of commercial drugs and the treatment of various conditions. The imidazole nucleus is present in many natural compounds and widely distributed in essential amino acids, such as l-histidine, whose derivatives exhibit powerful pharmacological properties. In this review, we delve into the historical timeline and development of synthetic pathways for tri- and tetra-substituted imidazoles used in the renowned Radziszewski reaction. Furthermore, we explore various bacteriological applications documented in the literature, as well as current advances in preclinical approaches to imidazole-based drug discovery. Tri- or tetra-substituted imidazole derivatives show strong potential for new synthesis methods, such as reflux or microwave, as well as various biological activities.
