The anesthetic sevoflurane induces tau trafficking from neurons to microglia

Yuanlin Dong; Feng Liang; Lining Huang; Fang Fang; Guang Yang; Rudolph E. Tanzi; Yiying Zhang; Qimin Quan; Zhongcong Xie

doi:10.1038/s42003-021-02047-8

Communications Biology (May 2021)

The anesthetic sevoflurane induces tau trafficking from neurons to microglia

Yuanlin Dong,
Feng Liang,
Lining Huang,
Fang Fang,
Guang Yang,
Rudolph E. Tanzi,
Yiying Zhang,
Qimin Quan,
Zhongcong Xie

Affiliations

Yuanlin Dong: Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School
Feng Liang: Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School
Lining Huang: Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School
Fang Fang: Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School
Guang Yang: Department of Anesthesiology, Columbia University Medical Center
Rudolph E. Tanzi: Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School
Yiying Zhang: Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School
Qimin Quan: Rowland Institute at Harvard University
Zhongcong Xie: Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School

DOI: https://doi.org/10.1038/s42003-021-02047-8
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 13

Abstract

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Using their previously developed nanobeam-sensor technology to detect tau protein in the blood, Yuanlin Dong et al. find that the anaesthetic sevoflurane induces trafficking of tau from neurons to microglia in mice. They further see that microglia can take up tau, leading to Il-6 production, overall bringing new insights into the mechanism of sevoflurane-mediated cognitive impairment.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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