mSystems
(Jun 2021)
Genomic and Phenotypic Evolution of Achromobacter xylosoxidans during Chronic Airway Infections of Patients with Cystic Fibrosis
S. M. Hossein Khademi,
Migle Gabrielaite,
Magnus Paulsson,
Mattis Knulst,
Eleni Touriki,
Rasmus L. Marvig,
Lisa I. Påhlman
Affiliations
S. M. Hossein Khademi
ORCiD
Department of Clinical Sciences Lund, Division of Infection Medicine, Lund University, Lund, Sweden
Migle Gabrielaite
ORCiD
Center for Genomic Medicine, Rigshospitalet, Copenhagen, Denmark
Magnus Paulsson
Department of Clinical Sciences Lund, Division of Infection Medicine, Lund University, Lund, Sweden
Mattis Knulst
Department of Clinical Sciences Lund, Division of Infection Medicine, Lund University, Lund, Sweden
Eleni Touriki
Clinical Microbiology, Labmedicin Skåne, Lund, Sweden
Rasmus L. Marvig
Center for Genomic Medicine, Rigshospitalet, Copenhagen, Denmark
Lisa I. Påhlman
Department of Clinical Sciences Lund, Division of Infection Medicine, Lund University, Lund, Sweden
DOI
https://doi.org/10.1128/mSystems.00523-21
Journal volume & issue
Vol. 6,
no. 3
Abstract
Read online
A thorough understanding of bacterial pathogen adaptation is essential for the treatment of chronic bacterial infections. One unique challenge in the analysis and interpretation of genomics data is identifying the function impact of mutations accumulated in the bacterial genome during colonization in the human host.
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