PLoS ONE (Jan 2015)

Evaluation of shear wave velocity and human bone morphogenetic protein-7 for the diagnosis of diabetic kidney disease.

  • Ning Yu,
  • Yue-yue Zhang,
  • Xiao-yan Niu,
  • Yan Xu,
  • Rui-xia Ma,
  • Wei Zhang,
  • Xiu-bo Jiang

DOI
https://doi.org/10.1371/journal.pone.0119713
Journal volume & issue
Vol. 10, no. 3
p. e0119713

Abstract

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The aim of this study was to determine the diagnostic values of kidney shear wave velocity (SWV) and bone morphogenetic protein-7 (BMP-7), and their correlation in the diagnosis of early diabetic kidney disease.A total of 150 patients with type 2 diabetes mellitus were divided into three equal groups based on the urinary albumin-creatinine ratio (ACR): normal albuminuria (normo- group, ACR 0.05). In addition, a significant correlation was found between SWV and BMP-7, with a coefficient of -0.569 (P < 0.05).The determination of SWV together with serum BMP-7 may play an important role in the diagnosis of diabetic kidney disease.