Neural Substrates of the Drift-Diffusion Model in Brain Disorders

Ankur Gupta; Rohini Bansal; Hany Alashwal; Anil Safak Kacar; Fuat Balci; Fuat Balci; Ahmed A. Moustafa; Ahmed A. Moustafa; Ahmed A. Moustafa

doi:10.3389/fncom.2021.678232

Frontiers in Computational Neuroscience (Jan 2022)

Neural Substrates of the Drift-Diffusion Model in Brain Disorders

Ankur Gupta,
Rohini Bansal,
Hany Alashwal,
Anil Safak Kacar,
Fuat Balci,
Fuat Balci,
Ahmed A. Moustafa,
Ahmed A. Moustafa,
Ahmed A. Moustafa

Affiliations

Ankur Gupta: CNRS UMR 5293, Institut des Maladies Neurodégénératives, Université de Bordeaux, Bordeaux, France
Rohini Bansal: Department of Medical Neurobiology, The Hebrew University of Jerusalem, Jerusalem, Israel
Hany Alashwal: College of Information Technology, United Arab Emirates University, Al-Ain, United Arab Emirates
Anil Safak Kacar: Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, Turkey
Fuat Balci: Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, Turkey
Fuat Balci: Department of Biological Sciences, University of Manitoba, Winnipeg, MB, Canada
Ahmed A. Moustafa: School of Psychology & Marcs Institute for Brain and Behaviour, Western Sydney University, Sydney, NSW, Australia
Ahmed A. Moustafa: School of Psychology, Faculty of Society and Design, Bond University, Robina, QLD, Australia
Ahmed A. Moustafa: Faculty of Health Sciences, Department of Human Anatomy and Physiology, University of Johannesburg, Johannesburg, South Africa

DOI: https://doi.org/10.3389/fncom.2021.678232
Journal volume & issue: Vol. 15

Abstract

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Many studies on the drift-diffusion model (DDM) explain decision-making based on a unified analysis of both accuracy and response times. This review provides an in-depth account of the recent advances in DDM research which ground different DDM parameters on several brain areas, including the cortex and basal ganglia. Furthermore, we discuss the changes in DDM parameters due to structural and functional impairments in several clinical disorders, including Parkinson's disease, Attention Deficit Hyperactivity Disorder (ADHD), Autism Spectrum Disorders, Obsessive-Compulsive Disorder (OCD), and schizophrenia. This review thus uses DDM to provide a theoretical understanding of different brain disorders.

Published in Frontiers in Computational Neuroscience

ISSN: 1662-5188 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/computational_neuroscience

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