Correction of cyclophosphan toxicity by polyphenolic hepatoprotectors

Abstract

Efficiency of lokhein, maksar and karsil hepatoprotectors in the treatment of cyclophosphan damaged liver has been investigated. Hepatoprotectors decrease the overall cytostatic toxicity, reduce the hepatocyte necrosis and the cell infiltration of liver parenchyma, cause the hyperaminotransferase and hyperbilirubin regression, stimulate the bilirubin conjugation and normalize the protein content in blood. Lokhein prevents most efficiently the development of morphologic disturbances in liver and recovers most of biochemical abnormalities at cyclophosphan intoxication.

Keywords

• гепатопротекторы
• лохеин
• максар
• карсил
• циклофосфан