Frontiers in Medicine (Jul 2021)
Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy
- Željka Večerić-Haler,
- Željka Večerić-Haler,
- Nika Kojc,
- Matjaž Sever,
- Matjaž Sever,
- Samo Zver,
- Samo Zver,
- Urban Švajger,
- Primož Poženel,
- Katrina Hartman,
- Tereza Urdih,
- Gregor Mlinšek,
- Gregor Mlinšek,
- Manca Oblak,
- Andreja Aleš Rigler,
- Alojz Ihan,
- Jadranka Buturović Ponikvar,
- Jadranka Buturović Ponikvar,
- Philip P. Halloran,
- Miha Arnol,
- Miha Arnol
Affiliations
- Željka Večerić-Haler
- Department of Nephrology, University Medical Centre Ljubljana, Ljubljana, Slovenia
- Željka Večerić-Haler
- Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
- Nika Kojc
- Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
- Matjaž Sever
- Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
- Matjaž Sever
- Department of Haematology, University Medical Centre Ljubljana, Ljubljana, Slovenia
- Samo Zver
- Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
- Samo Zver
- Department of Haematology, University Medical Centre Ljubljana, Ljubljana, Slovenia
- Urban Švajger
- Division for Cells and Tissue, Blood Transfusion Centre of Slovenia, Ljubljana, Slovenia
- Primož Poženel
- Division for Cells and Tissue, Blood Transfusion Centre of Slovenia, Ljubljana, Slovenia
- Katrina Hartman
- Division for Cells and Tissue, Blood Transfusion Centre of Slovenia, Ljubljana, Slovenia
- Tereza Urdih
- Department of Haematology, University Medical Centre Ljubljana, Ljubljana, Slovenia
- Gregor Mlinšek
- Department of Nephrology, University Medical Centre Ljubljana, Ljubljana, Slovenia
- Gregor Mlinšek
- Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
- Manca Oblak
- Department of Nephrology, University Medical Centre Ljubljana, Ljubljana, Slovenia
- Andreja Aleš Rigler
- Department of Nephrology, University Medical Centre Ljubljana, Ljubljana, Slovenia
- Alojz Ihan
- Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
- Jadranka Buturović Ponikvar
- Department of Nephrology, University Medical Centre Ljubljana, Ljubljana, Slovenia
- Jadranka Buturović Ponikvar
- Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
- Philip P. Halloran
- Division of Nephrology and Transplant Immunology, University of Alberta, Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada
- Miha Arnol
- Department of Nephrology, University Medical Centre Ljubljana, Ljubljana, Slovenia
- Miha Arnol
- Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
- DOI
- https://doi.org/10.3389/fmed.2021.708744
- Journal volume & issue
-
Vol. 8
Abstract
Mesenchymal stem cells (MSCs) have attracted great interest in the field of kidney transplantation due to their immunomodulatory and reparative properties. In registered clinical trials, MSCs have been used before, at the time of, or early after transplantation and have been reported to be well-tolerated with no serious safety concerns. No results are available on the use of MSCs in the late post-transplant period. Here, we present a case report of a severe systemic complication mimicking capillary leak syndrome with ultimate kidney transplant failure after autologous transplantation of MSCs used as rescue treatment of late antibody-mediated kidney allograft rejection.
Keywords
- mesenchymal stem cell
- kidney graft
- kidney transplant
- kidney graft failure
- autologous stem cell
- stem cell transplant
