International Journal of Gerontology (Mar 2017)

cIAP-2 Expression Increases in Elderly Patients with Squamous Cell Carcinoma of the Head and Neck

  • Chi-Long Chen,
  • Chun-Yi Chiang,
  • Kuang-Wen Liao,
  • Shu-Yi Ho,
  • Yi-Fang Chang,
  • Ken-Hong Lim,
  • Ruey-Kuen Hsieh,
  • Yu-Ling Lin,
  • Ying-Wen Su

DOI
https://doi.org/10.1016/j.ijge.2016.04.003
Journal volume & issue
Vol. 11, no. 1
pp. 22 – 26

Abstract

Read online

Background: Evidence indicates apoptosis deregulation is associated with aging. We correlated expression of cIAP-2, a member of the inhibitor of apoptosis protein family, with survival and age in patients with resected squamous cell carcinoma of head and neck (SCCHN). Methods: Immunohistochemical (IHC) staining for cIAP-2 and other markers were performed using tissue microarrays from 103 resected SCCHN patients. Expression was grouped according to IHC scores (0–3) and statistical association with clinical–pathological factors was determined. Results: High expression of cIAP-2 was found to be increased in patients aged 60 or greater. High expression of cIAP-2 and an age ≥60 were significantly associated with worse survival in univariate analysis, but only an age ≥60, and not cIAP-2 expression, was prognostic in multivariate analysis. Conclusion: High expression of cIAP-2 was found more frequently in elderly SCCHN patients but was not independently associated with survival after adjusting other clinical–pathologic factors.

Keywords