The Invivo activity of Lavandula angustifolia on Giardia lamblia in souri miceThe Invivo activity of Lavandula angustifolia on Giardia lamblia in souri mice

Abstract

Introduction Giardia lamblia is one of the most prevalent flagellate protozoa in human with the world-wide distribution. Millions of people are affected by Giardiasis annually. Today, many treatments are available for giardiasis that associated with some side effects. This study is aimed to evaluate the antigiardial activity of Lavandula angustifolia in vivo. Materials and Methods In this study 25 mice are categorized in 5 groups include; Control group (without any treatment), Positive control (treatment by Metronidazole) and other three groups (treatment by 100, 200 and 400 mg/ml of Plant extracts). Then, after 10 days, the effects of each group are evaluated on the Giardia lamblia. The statistical methods used were based on one-way variance analysis and paired t-comparison that were used in the usual way for normal values in the Bootstrap method for values that were not distributed normalized according to the low sample size. Results In this study, the body weights of treated mice with different extracts were more than the positive control and less than the negative control. Also, the live cysts were decreased 77.7, 83.4 and 95.1% by the use of 100, 200 and 400 mg/ml of plant extracts. Conclusion The results of the current study indicated that Lavandula angustifolia has conceivable effects in vivo and it will be a suitable alternative for treatment of Giardiasis.

Keywords

• Giardia lamblia
• Lavandula angustifolia
• Souri mice
• Infection