Nature Communications (Feb 2016)

Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo

  • Igor Pavlovic,
  • Divyeshsinh T. Thakor,
  • Jessica R. Vargas,
  • Colin J. McKinlay,
  • Sebastian Hauke,
  • Philipp Anstaett,
  • Rafael C. Camuña,
  • Laurent Bigler,
  • Gilles Gasser,
  • Carsten Schultz,
  • Paul A. Wender,
  • Henning J. Jessen

DOI
https://doi.org/10.1038/ncomms10622
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 8

Abstract

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Photocaged inositol-pyrophosphates offer a tool to study cellular signalling, but their challenging synthesis has precluded any biological studies so far. Here, the authors report the synthesis and cellular delivery of a photocaged analogue, and show that it mediates protein translocation in cellulo.