Nature Communications (May 2018)

A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell

  • Yasunori Okamoto,
  • Ryosuke Kojima,
  • Fabian Schwizer,
  • Eline Bartolami,
  • Tillmann Heinisch,
  • Stefan Matile,
  • Martin Fussenegger,
  • Thomas R. Ward

DOI
https://doi.org/10.1038/s41467-018-04440-0
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 7

Abstract

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Artificial enzymes can be used to elicit reactions in cells. Here, the authors developed such an artificial catalyst combined with a genetic switch, and showed that it was readily taken up by human cells and able to kick off a reaction cascade resulting in the biosynthesis of the desired product.