Nature Communications (Jun 2022)
Asgard archaea shed light on the evolutionary origins of the eukaryotic ubiquitin-ESCRT machinery
- Tomoyuki Hatano,
- Saravanan Palani,
- Dimitra Papatziamou,
- Ralf Salzer,
- Diorge P. Souza,
- Daniel Tamarit,
- Mehul Makwana,
- Antonia Potter,
- Alexandra Haig,
- Wenjue Xu,
- David Townsend,
- David Rochester,
- Dom Bellini,
- Hamdi M. A. Hussain,
- Thijs J. G. Ettema,
- Jan Löwe,
- Buzz Baum,
- Nicholas P. Robinson,
- Mohan Balasubramanian
Affiliations
- Tomoyuki Hatano
- Centre for Mechanochemical Cell Biology, Division of Biomedical Sciences, Warwick Medical School, University of Warwick
- Saravanan Palani
- Centre for Mechanochemical Cell Biology, Division of Biomedical Sciences, Warwick Medical School, University of Warwick
- Dimitra Papatziamou
- Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University
- Ralf Salzer
- MRC Laboratory of Molecular Biology
- Diorge P. Souza
- MRC Laboratory of Molecular Biology
- Daniel Tamarit
- Laboratory of Microbiology, Wageningen University
- Mehul Makwana
- Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University
- Antonia Potter
- Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University
- Alexandra Haig
- Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University
- Wenjue Xu
- Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University
- David Townsend
- Department of Chemistry, Lancaster University
- David Rochester
- Department of Chemistry, Lancaster University
- Dom Bellini
- MRC Laboratory of Molecular Biology
- Hamdi M. A. Hussain
- Centre for Mechanochemical Cell Biology, Division of Biomedical Sciences, Warwick Medical School, University of Warwick
- Thijs J. G. Ettema
- Laboratory of Microbiology, Wageningen University
- Jan Löwe
- MRC Laboratory of Molecular Biology
- Buzz Baum
- MRC Laboratory of Molecular Biology
- Nicholas P. Robinson
- Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University
- Mohan Balasubramanian
- Centre for Mechanochemical Cell Biology, Division of Biomedical Sciences, Warwick Medical School, University of Warwick
- DOI
- https://doi.org/10.1038/s41467-022-30656-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
The ESCRT pathway is crucial for membrane remodelling in eukaryotes. Here, Hatano et al. explore the phylogeny, structure, and biochemistry of homologues of the ESCRT machinery and the associated ubiquitylation system in Asgard archaea, the closest living relatives of eukaryotes.
