Nature Communications (Jan 2021)

Direct control of CAR T cells through small molecule-regulated antibodies

  • Spencer Park,
  • Edward Pascua,
  • Kevin C. Lindquist,
  • Christopher Kimberlin,
  • Xiaodi Deng,
  • Yvonne S. L. Mak,
  • Zea Melton,
  • Theodore O. Johnson,
  • Regina Lin,
  • Bijan Boldajipour,
  • Robert T. Abraham,
  • Jaume Pons,
  • Barbra Johnson Sasu,
  • Thomas J. Van Blarcom,
  • Javier Chaparro-Riggers

DOI
https://doi.org/10.1038/s41467-020-20671-6
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

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Many next-generation antibody therapeutics have enhanced potency but the risk of adverse events. Here the authors develop a conditionally activated, single-module CAR.