SWI/SNF chromatin remodeling factor BAF60b restrains inflammatory diseases by affecting regulatory T cell migration
Xiaoqian Liu,
Kuai Liu,
Yuxi Wang,
Xiaoyu Meng,
Qianqian Wang,
Sijue Tao,
Qianying Xu,
Xin Shen,
Xianzhi Gao,
Shenghui Hong,
Huihui Jin,
James Q. Wang,
Di Wang,
Linrong Lu,
Zhuoxian Meng,
Lie Wang
Affiliations
Xiaoqian Liu
Institute of Immunology and Bone Marrow Transplantation Center, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 311100, China; Zhejiang University School of Medicine, Hangzhou 310058, China
Kuai Liu
Institute of Immunology and Bone Marrow Transplantation Center, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 311100, China; Zhejiang University School of Medicine, Hangzhou 310058, China
Yuxi Wang
Laboratory Animal Center, Zhejiang University, Hangzhou 310058, China
Xiaoyu Meng
Institute of Immunology and Bone Marrow Transplantation Center, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 311100, China; Zhejiang University School of Medicine, Hangzhou 310058, China
Qianqian Wang
Laboratory Animal Center, Zhejiang University, Hangzhou 310058, China
Sijue Tao
Laboratory Animal Center, Zhejiang University, Hangzhou 310058, China
Qianying Xu
Zhejiang University School of Medicine, Hangzhou 310058, China
Xin Shen
Co-Facility Center, Zhejiang University School of Medicine, Hangzhou 310058, China
Xianzhi Gao
Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou 311100, China; Zhejiang University School of Medicine, Hangzhou 310058, China
Shenghui Hong
Laboratory Animal Center, Zhejiang University, Hangzhou 310058, China
Huihui Jin
Laboratory Animal Center, Zhejiang University, Hangzhou 310058, China
James Q. Wang
Zhejiang University School of Medicine, Hangzhou 310058, China; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 314400, China
Di Wang
Zhejiang University School of Medicine, Hangzhou 310058, China
Linrong Lu
Zhejiang University School of Medicine, Hangzhou 310058, China
Zhuoxian Meng
Department of Pathology and Pathophysiology and Department of Cardiology, School of Medicine, Second Affiliated Hospital, Zhejiang University, Hangzhou 310009, China
Lie Wang
Institute of Immunology and Bone Marrow Transplantation Center, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 311100, China; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou 311100, China; Zhejiang University School of Medicine, Hangzhou 310058, China; Laboratory Animal Center, Zhejiang University, Hangzhou 310058, China; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 314400, China; Future Health Laboratory, Innovation Center of Yangtze River Delta, Zhejiang University, Jiaxing 314100, China; Corresponding author
Summary: Regulatory T (Treg) cells play a critical regulatory role in the immune system by suppressing excessive immune responses and maintaining immune balance. The effective migration of Treg cells is crucial for controlling the development and progression of inflammatory diseases. However, the mechanisms responsible for directing Treg cells into the inflammatory tissue remain incompletely elucidated. In this study, we identified BAF60b, a subunit of switch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complexes, as a positive regulator of Treg cell migration that inhibits the progression of inflammation in experimental autoimmune encephalomyelitis (EAE) and colitis animal models. Mechanistically, transcriptome and genome-wide chromatin-landscaped analyses demonstrated that BAF60b interacts with the transcription factor RUNX1 to promote the expression of CCR9 on Treg cells, which in turn affects their ability to migrate to inflammatory tissues. Our work provides insights into the essential role of BAF60b in regulating Treg cell migration and its impact on inflammatory diseases.
