Nature Communications (Nov 2022)
Postnatal expansion of mesenteric lymph node stromal cells towards reticular and CD34+ stromal cell subsets
- Joern Pezoldt,
- Carolin Wiechers,
- Mangge Zou,
- Maria Litovchenko,
- Marjan Biocanin,
- Michael Beckstette,
- Katarzyna Sitnik,
- Martina Palatella,
- Guido van Mierlo,
- Wanze Chen,
- Vincent Gardeux,
- Stefan Floess,
- Maria Ebel,
- Julie Russeil,
- Panagiota Arampatzi,
- Ehsan Vafardanejad,
- Antoine-Emmanuel Saliba,
- Bart Deplancke,
- Jochen Huehn
Affiliations
- Joern Pezoldt
- Department Experimental Immunology, Helmholtz Centre for Infection Research
- Carolin Wiechers
- Department Experimental Immunology, Helmholtz Centre for Infection Research
- Mangge Zou
- Department Experimental Immunology, Helmholtz Centre for Infection Research
- Maria Litovchenko
- Laboratory of Systems Biology and Genetics, École Polytechnique Fédérale de Lausanne
- Marjan Biocanin
- Laboratory of Systems Biology and Genetics, École Polytechnique Fédérale de Lausanne
- Michael Beckstette
- Department Experimental Immunology, Helmholtz Centre for Infection Research
- Katarzyna Sitnik
- Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna
- Martina Palatella
- Department Experimental Immunology, Helmholtz Centre for Infection Research
- Guido van Mierlo
- Laboratory of Systems Biology and Genetics, École Polytechnique Fédérale de Lausanne
- Wanze Chen
- Laboratory of Systems Biology and Genetics, École Polytechnique Fédérale de Lausanne
- Vincent Gardeux
- Laboratory of Systems Biology and Genetics, École Polytechnique Fédérale de Lausanne
- Stefan Floess
- Department Experimental Immunology, Helmholtz Centre for Infection Research
- Maria Ebel
- Department Experimental Immunology, Helmholtz Centre for Infection Research
- Julie Russeil
- Laboratory of Systems Biology and Genetics, École Polytechnique Fédérale de Lausanne
- Panagiota Arampatzi
- Core Unit Systems Medicine, University of Wuerzburg
- Ehsan Vafardanejad
- Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Center for Infection Research (HZI)
- Antoine-Emmanuel Saliba
- Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Center for Infection Research (HZI)
- Bart Deplancke
- Laboratory of Systems Biology and Genetics, École Polytechnique Fédérale de Lausanne
- Jochen Huehn
- Department Experimental Immunology, Helmholtz Centre for Infection Research
- DOI
- https://doi.org/10.1038/s41467-022-34868-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Lymph nodes in various locations of the body differ in their cell composition and gene expression signatures. Here authors show that the rapid postnatal expansion of lymph nodes is governed by CD34 + stromal cells and fibroblastic reticular stromal cell progenitors, distinguished by intrinsic, microbiome-independent core epigenetic blueprints.
