Nature Communications (Sep 2022)

A stem cell roadmap of ribosome heterogeneity reveals a function for RPL10A in mesoderm production

  • Naomi R. Genuth,
  • Zhen Shi,
  • Koshi Kunimoto,
  • Victoria Hung,
  • Adele F. Xu,
  • Craig H. Kerr,
  • Gerald C. Tiu,
  • Juan A. Oses-Prieto,
  • Rachel E. A. Salomon-Shulman,
  • Jeffrey D. Axelrod,
  • Alma L. Burlingame,
  • Kyle M. Loh,
  • Maria Barna

DOI
https://doi.org/10.1038/s41467-022-33263-3
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 19

Abstract

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How ribosomes differ in composition and function to regulate gene expression is poorly understood. Here, the authors show that ribosome composition changes during stem cell differentiation and identify a ribosomal protein that regulates production of the mesoderm lineage.