Nature Communications (Dec 2017)
Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms
- Qiue Yang,
- Mei Li,
- Owen B. Spiller,
- Diego O. Andrey,
- Philip Hinchliffe,
- Hui Li,
- Craig MacLean,
- Pannika Niumsup,
- Lydia Powell,
- Manon Pritchard,
- Andrei Papkou,
- Yingbo Shen,
- Edward Portal,
- Kirsty Sands,
- James Spencer,
- Uttapoln Tansawai,
- David Thomas,
- Shaolin Wang,
- Yang Wang,
- Jianzhong Shen,
- Timothy Walsh
Affiliations
- Qiue Yang
- Department of Medical Microbiology and Infectious Disease, Division of Infection and Immunity, Cardiff University
- Mei Li
- Department of Medical Microbiology and Infectious Disease, Division of Infection and Immunity, Cardiff University
- Owen B. Spiller
- Department of Medical Microbiology and Infectious Disease, Division of Infection and Immunity, Cardiff University
- Diego O. Andrey
- Department of Medical Microbiology and Infectious Disease, Division of Infection and Immunity, Cardiff University
- Philip Hinchliffe
- School of Cellular and Molecular Medicine, University of Bristol
- Hui Li
- Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control
- Craig MacLean
- Department of Zoology, University of Oxford
- Pannika Niumsup
- Department of Microbiology and Parasitology, Faculty of Medical Science, Naresuan University
- Lydia Powell
- Advanced Therapies Group, Oral and Biomedical Sciences, School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Heath Park
- Manon Pritchard
- Advanced Therapies Group, Oral and Biomedical Sciences, School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Heath Park
- Andrei Papkou
- Department of Zoology, University of Oxford
- Yingbo Shen
- Beijing Advanced Innovation Centre for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University
- Edward Portal
- Department of Medical Microbiology and Infectious Disease, Division of Infection and Immunity, Cardiff University
- Kirsty Sands
- Department of Medical Microbiology and Infectious Disease, Division of Infection and Immunity, Cardiff University
- James Spencer
- School of Cellular and Molecular Medicine, University of Bristol
- Uttapoln Tansawai
- Department of Microbiology and Parasitology, Faculty of Medical Science, Naresuan University
- David Thomas
- Advanced Therapies Group, Oral and Biomedical Sciences, School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Heath Park
- Shaolin Wang
- Beijing Advanced Innovation Centre for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University
- Yang Wang
- Beijing Advanced Innovation Centre for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University
- Jianzhong Shen
- Beijing Advanced Innovation Centre for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University
- Timothy Walsh
- Department of Medical Microbiology and Infectious Disease, Division of Infection and Immunity, Cardiff University
- DOI
- https://doi.org/10.1038/s41467-017-02149-0
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
The plasmid-encoded MCR-1 enzyme modifies bacterial lipid A, thus conferring resistance to the antibiotic colistin. Here, Yang et al. show that MCR-1 expression can decrease in vitro growth rate, fitness and immune stimulation, and can reduce virulence in a Galleria mellonella infection model.
