Association Between Lipid Accumulation Product and Stress Urinary Incontinence in Women in the United States: The Mediating Role of Oxidative Stress

Abstract

Purpose The relationship between lipid accumulation product (LAP) and stress urinary incontinence (SUI) in women remains unclear, and the potential mediating roles of oxidative stress and inflammatory factors in this process have not been extensively studied. This analysis aimed to explore the association between elevated LAP indices and SUI in women, specifically examining the mediating effects of oxidative stress and inflammatory factors. Methods Data from 4,292 participants across 6 consecutive cycles of the National Health and Nutrition Examination Survey were analyzed. Logistic regression and subgroup analyses, adjusted for various covariates, were performed to investigate the relationship between LAP and the prevalence of SUI in adult women. Additionally, mediation analysis was conducted to evaluate the contributions of oxidative stress and inflammatory factors to this association. Results The prevalence of SUI among women in the United States was 46.02%. After adjustment for confounding factors, the odds ratio for LAP and SUI was 1.003 (95% confidence interval, 1.001–1.004; P=0.002), indicating a positive association. Gamma-glutamyl transferase mediated this relationship, explaining 40.0% of the effect (P=0.036). Conclusions This study’s findings indicate a positive association between LAP and the prevalence of SUI in women, with oxidative stress potentially acting as a mediator in this relationship.

Keywords

• nutrition surveys
• lipid accumulation product
• stress urinary incontinence
• mediation analysis
• oxidative stress