Nature Communications (Jul 2020)
ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment
- Chi-Lam Au-Yeung,
- Tsz-Lun Yeung,
- Abhinav Achreja,
- Hongyun Zhao,
- Kay-Pong Yip,
- Suet-Ying Kwan,
- Michaela Onstad,
- Jianting Sheng,
- Ying Zhu,
- Dodge L. Baluya,
- Ngai-Na Co,
- Angela Rynne-Vidal,
- Rosemarie Schmandt,
- Matthew L. Anderson,
- Karen H. Lu,
- Stephen T. C. Wong,
- Deepak Nagrath,
- Samuel C. Mok
Affiliations
- Chi-Lam Au-Yeung
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- Tsz-Lun Yeung
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- Abhinav Achreja
- Department of Biomedical Engineering, University of Michigan
- Hongyun Zhao
- Department of Biomedical Engineering, University of Michigan
- Kay-Pong Yip
- Department of Molecular Pharmacology and Physiology, University of South Florida
- Suet-Ying Kwan
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- Michaela Onstad
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- Jianting Sheng
- Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Weill Cornell Medicine
- Ying Zhu
- Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Weill Cornell Medicine
- Dodge L. Baluya
- Department of Diagnostic Imaging-Interventional Radiology, The University of Texas MD Anderson Cancer Center
- Ngai-Na Co
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- Angela Rynne-Vidal
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- Rosemarie Schmandt
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- Matthew L. Anderson
- Department of Obstetrics and Gynecology, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Karen H. Lu
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- Stephen T. C. Wong
- Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Weill Cornell Medicine
- Deepak Nagrath
- Department of Biomedical Engineering, University of Michigan
- Samuel C. Mok
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-020-17383-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
Advanced ovarian cancer usually spreads to the omentum. Here, the authors show that circulating intelectin-1 (ITLN1) has prognostic significance in patients with advanced ovarian cancer, and that mesothelial cell-derived ITLN1 in the omental tumor microenvironment suppresses ovarian cancer progression.
