Nature Communications (Aug 2019)

Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease

  • Jian Jing Siew,
  • Hui-Mei Chen,
  • Huan-Yuan Chen,
  • Hung-Lin Chen,
  • Chiung-Mei Chen,
  • Bing-Wen Soong,
  • Yih-Ru Wu,
  • Ching-Pang Chang,
  • Yi-Chen Chan,
  • Chun-Hung Lin,
  • Fu-Tong Liu,
  • Yijuang Chern

DOI
https://doi.org/10.1038/s41467-019-11441-0
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 18

Abstract

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The authors show that Galectin-3 is up–regulated in brain tissues from patients and a mouse model of Huntington’s disease (HD) and correlates with disease severity. Galectin-3 accumulates at damaged lysosomes in HD microglia, prevents the clearance of damaged lysosomes, and promotes inflammation.